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2.1.1.345: psilocybin synthase

This is an abbreviated version!
For detailed information about psilocybin synthase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

4-hydroxytryptamine 4-phosphate
= 2 S-adenosyl-L-homocysteine +
psilocybin

Synonyms

PsiM

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.345 psilocybin synthase

Engineering

Engineering on EC 2.1.1.345 - psilocybin synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D161A
the variant is as active as the wild-type enzyme in in vitro assays
N183A
the variant is catalytically inactive
R75A
the variant is catalytically inactive
S196A
inactive variant
Y187A
the variant is catalytically inactive