2.1.1.342: anaerobilin synthase

This is an abbreviated version!
For detailed information about anaerobilin synthase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

chuW

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.342 anaerobilin synthase

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Results	in table
1	AA Sequence
2	Cofactor
1	Expression
2	General Information
1	General Stability
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
3	Organism
1	Pathway
1	Reaction
3	Reference
1	Specific Activity [micromol/min/mg]
5	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.342 - anaerobilin synthase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:protoheme C-methyltransferase (anaerobilin-producing)

The enzyme, studied from the bacterium Escherichia coli O157:H7, is a radical SAM (AdoMet) enzyme that is involved in heme degradation and iron utilization under anaerobic conditions. The enzyme uses two SAM molecules for the reaction. The first molecule is used to generate a 5'-deoxyadenosyl radical, which abstracts a hydrogen atom from the methyl group of the second SAM molecule. The newly formed methylene radical attacks the substrate, causing a rearrangement of the porphyrin ring that results in the liberation of iron.