2.1.1.319: type I protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type I protein arginine methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

arginine methyltransferase 1, CARM1, coactivator-associated arginine methyltransferase 1, coactivator-associated arginine methyltransferase 1 variant 5, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Eucgr.C03665.1, PRMT I, PRMT-1, PRMT1, PRMT10, PRMT2, PRMT3, PRMT4, PRMT6, PRMT8, protein arginine methyltransferase 1, protein arginine methyltransferase 2, protein arginine methyltransferase 4, protein arginine methyltransferase 6, protein arginine methyltransferase I, protein arginine N-methyltransferase 2, protein arginine N-methyltransferase I, RMT1, Tb927.1.4690, Tb927.5.3960, type I protein arginine methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.319 type I protein arginine methyltransferase

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Results	in table
1	Activating Compound
1763	AA Sequence
6	Application
7	Cloned(Commentary)
4	Crystallization (Commentary)
1921	Disease/ Diagnostics
11	Expression
49	General Information
32	IC50 Value
44	Inhibitors
12	kcat/KM [mM/s]
3	Ki Value [mM]
12	KM Value [mM]
11	Localization
5	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
55	Organism
241	PDB ID
1	pH Optimum
1	Posttranslational Modification
4	Protein Variants
5	Purification (Commentary)
3	Reaction
49	Reference
79	Source Tissue
1	Specific Activity [micromol/min/mg]
76	Substrates and Products (Substrate)
2	Subunits
99	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
12	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.319 - type I protein arginine methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 S-adenosyl-L-methionine + [beta-tubulin]-L-arginine

2 S-adenosyl-L-homocysteine + [beta-tubulin]-Nomega,Nomega-dimethyl-L-arginine

Eucalyptus grandis

-

-

756308

-

-

?

2 S-adenosyl-L-methionine + [CBP/p300]-L-arginine

2 S-adenosyl-L-homocysteine + [CBP/p300]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q86X55

-

757564

-

-

?

2 S-adenosyl-L-methionine + [coiled-coil domain of p54nrb]-L-arginine

2 S-adenosyl-L-homocysteine + [coiled-coil domain of p54nrb]-Nomega,Nomega-dimethyl-L-arginine

Mus musculus

Q9WVG6

the enzyme (CARM1) regulates this nuclear retention pathway at two levels: CARM1 methylates the coiled-coil domain of p54nrb, resulting in reduced binding of p54nrb to mRNAs containing inverted repeated Alu elements (IRAlus), and also acts as a transcription regulator to suppress NEAT1 transcription, leading to reduced paraspeckle formation. These actions of CARM1 work together synergistically to regulate the export of transcripts containing IRAlus from paraspeckles under certain cellular stresses, such as poly(I:C) treatment

756878

-

-

?

2 S-adenosyl-L-methionine + [histone H3R17]-L-arginine

2 S-adenosyl-L-homocysteine + [histone H3R17]-Nomega,Nomega-dimethyl-L-arginine

2 entries

2 S-adenosyl-L-methionine + [histone H3R26]-L-arginine

2 S-adenosyl-L-homocysteine + [histone H3R26]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q86X55

-

757564

-

-

?

2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine

2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega-dimethyl-L-arginine

2 entries

2 S-adenosyl-L-methionine + [NCOA2]-L-arginine

2 S-adenosyl-L-homocysteine + [NCOA2]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q86X55

-

757564

-

-

?

2 S-adenosyl-L-methionine + [PABP1]-L-arginine

2 S-adenosyl-L-homocysteine + [PABP1]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q86X55

-

757564

-

-

?

2 S-adenosyl-L-methionine + [SAP49]-L-arginine

2 S-adenosyl-L-homocysteine + [SAP49]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q86X55

-

757564

-

-

?

2 S-adenosyl-L-methionine + [SRC-3]-L-arginine

2 S-adenosyl-L-homocysteine + [SRC-3]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q86X55

-

757564

-

-

?

2 S-adenosyl-L-methionine + [histone H3R17]-L-arginine

2 S-adenosyl-L-homocysteine + [histone H3R17]-Nomega,Nomega-dimethyl-L-arginine

Gallus gallus

A0A2D3I4C6

-

756732

-

-

?

2 S-adenosyl-L-methionine + [histone H3R17]-L-arginine

2 S-adenosyl-L-homocysteine + [histone H3R17]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q86X55

-

757564

-

-

?

2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine

2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

-

-

756229

-

-

?

2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine

2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega-dimethyl-L-arginine

Homo sapiens

Q99873

-

756181

-

-

?