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2.1.1.314: diphthine methyl ester synthase

This is an abbreviated version!
For detailed information about diphthine methyl ester synthase, go to the full flat file.

Reaction

4 S-adenosyl-L-methionine +

2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2]
= 4 S-adenosyl-L-homocysteine +
diphthine methyl ester-[translation elongation factor 2]

Synonyms

diphthine methyltransferase, diphthine synthase, Dph5, S-adenosyl-L-methionine:elongation factor 2 methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.314 diphthine methyl ester synthase

Engineering

Engineering on EC 2.1.1.314 - diphthine methyl ester synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D57G
mutant retains activity
delA212
frequently occurring DPH5 isoform retained activity
E60stop
inactive mutant containing intact N-terminus with truncations after amino acid 207
G87R
mutant retains activity
Q170H
mutant retains activity
R207stop
inactive mutant containing intact N-terminus with truncations after amino acid 207
S123C
mutant retains activity
W136stop
inactive mutant containing intact N-terminus with truncations after amino acid 207