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2.1.1.283: emodin O-methyltransferase

This is an abbreviated version!
For detailed information about emodin O-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
emodin
=
S-adenosyl-L-homocysteine
 +
Questin

Synonyms

CGZ69_28180, EOMT, More, O-methyltransferase, OMT, SpOMT7740

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.283 emodin O-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.283 - emodin O-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1,3,8-trihydroxy-6-methoxy-9,10-anthraquinone
?
show the reaction diagram
S-adenosyl-L-methionine + 3,5,7,8,3',4'-hexahydroxyflavone
S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8-methoxyflavone
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3-hydroxyflavone
S-adenosyl-L-homocysteine + 3-methoxyflavone
show the reaction diagram
lower activity
-
-
?
S-adenosyl-L-methionine + 7,8-dihydroxyflavone
S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxyflavone
show the reaction diagram
best substrate
-
-
?
S-adenosyl-L-methionine + 7-chloroemodin
?
show the reaction diagram
S-adenosyl-L-methionine + aloe emodin
S-adenosyl-L-homocysteine + 8-methoxy-1-hydroxy-3-(hydroxymethyl)anthracene-9,10-dione
show the reaction diagram
low activity
-
-
?
S-adenosyl-L-methionine + beta-sitosterol
S-adenosyl-L-homocysteine + 3-methoxy-beta-sitosterol
show the reaction diagram
low activity
-
-
?
S-adenosyl-L-methionine + catenarin
?
show the reaction diagram
S-adenosyl-L-methionine + emodin
S-adenosyl-L-homocysteine + questin
show the reaction diagram
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + O-methoxy-genistein
show the reaction diagram
when genistein is used as substrate, mass spectras of three O-methoxy genistein (mono-, di-, and tri-O-methoxy genistein) are detected, low activity
-
-
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + mono-methoxy-luteolin
show the reaction diagram
lower activity
-
-
?
S-adenosyl-L-methionine + phloretin
S-adenosyl-L-homocysteine + mono-methoxy-phloretin
show the reaction diagram
lower activity
-
-
?
additional information
?
-
the enzyme shows a broad substrate specificity. SpOMT7740 catalyzes the O-methylation reaction to form various natural and non-natural O-methoxides, includes 7-hydroxy-8-O-methoxy flavone, 3-O-methoxy flavone, three mono-, di-, and tri-O-methoxy genistein, mono-O-methoxy phloretin, mono-O-methoxy luteolin, 3-O-methoxy beta-sitosterol, and O-methoxy anthraquinones (emodin and aloe emodin) and O-methoxy anthracycline (daunorubicin) exhibiting diverse substrate flexibility. Mass spectrometric analysis of reaction products. 7,8-Dihydroxyflavone is the best substrate for bioconversion to 7-hydroxy-8-O-methoxy flavone. The enzyme seems to prefer methylation of hydroxy groups at C8 position. No or poor activity with doxorubicin and daunorubicin
-
-
-