2.1.1.228: tRNA (guanine37-N1)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (guanine37-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.228

2.1.1.228

methyltransferases

anticodon

adomet

1-methylguanosine

drug development

n2-guanine

trmt10a

1-methyladenine

adomet-dependent

5-methyluridine

trmfo

n1-methylation

methyl-deficient

7-methylguanine

spout

epitranscriptome

nsun2-mediated

medicine

Reaction

S-adenosyl-L-methionine

+

guanine37 in tRNA

=

S-adenosyl-L-homocysteine

+

N1-methylguanine37 in tRNA

Synonyms

At3g56120, aTrm5a methyltransferase, aTrm5a/Taw22-like enzyme, AtTrm5a, bacterial tRNA (guanine37-N1)-methyltransferase, bacterial tRNA-(N1G37) methyltransferase, EC 2.1.1.31, EcTrmD, HiTrmD, HsTrm5, m1G37 tRNA methyltransferase, m1G37-forming tRNA methyltransferase, Mj-Trm5, MJ0883, MjTrm5, MjTrm5b, mono-functional methyltransferase, More, MtbTrmD, NEQ228, PA14_15990, PAB2272, PAB_RS03940, PaTrm5a, PaTrm5b, PaTrmD, SaTrmD, Ta0997, TAW22, transfer RNA (m1G37) methyltransferase, Trm1, TRM5, Trm5a, Trm5a/Taw22-like enzyme, trm5b, Trm5p, TrmD, TRMT5, tRNA (guanine(37)-N1)-methyltransferase 1, tRNA (guanine37-N1)-methyltransferase, tRNA (guanosine-1) methyltransferase, tRNA (m1G37) methyltransferase, tRNA (m1G37)-methyltransferase, tRNA m1G37 methyltransferase, tRNA methyltransferase, tRNA methyltransferase 5, tRNA methyltransferase D, tRNA(m(1)G37)methyltransferase, tRNA(m1G37) methyltransferase, tRNA(m1G37) MTase, tRNA(m1G37)methyltransferase, tRNA-(N1G37) methyltransferase, tRNAPhe:imG2 methyltransferase

ECTree

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.228 tRNA (guanine37-N1)-methyltransferase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	Activating Compound
43500	AA Sequence
16	Application
31	Cloned(Commentary)
49	Cofactor
17	Crystallization (Commentary)
98	Disease/ Diagnostics
3	Expression
219	General Information
3	General Stability
89	IC50 Value
190	Inhibitors
40	kcat/KM [mM/s]
27	Ki Value [mM]
91	KM Value [mM]
8	Localization
44	Metals/Ions
8	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
168	Organism
3	Pathway
201	PDB ID
29	pH Optimum
5	pH Range
126	Protein Variants
23	Purification (Commentary)
9	Reaction
103	Reference
3	Source Tissue
269	Substrates and Products (Substrate)
58	Subunits
226	Synonyms
1	Systematic Name
28	Temperature Optimum [°C]
3	Temperature Stability [°C]
43	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

IC50 Value on EC 2.1.1.228 - tRNA (guanine37-N1)-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

back to the top

Go to IC50 Value Search

0.0092

(4-aminoquinazolin-2-yl)methyl 3-aminopyrazine-2-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0017

(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)methyl 2-(furan-2-yl)quinoline-4-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0049

1-(1H-pyrrol-2-yl)-2-[(thieno[2,3-d]pyrimidin-4-yl)oxy]ethan-1-one

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.013

1-(2-phenylpyrimidin-4-yl)-N-[(4-propoxyphenyl)methyl]piperidine-4-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0017

1-(3-chlorophenyl)-5-ethyl-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.00011

1-[(2-chlorophenyl)methyl]-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0058

1-[7-(3,4-dimethylbenzoyl)-2H-[1,3]dioxolo[4,5-g]quinolin-8-yl]piperidine-4-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0038

2-(1H-inden-2-yl)-5-[2-(1H-indol-3-yl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0011

2-(5-chlorothiophen-2-yl)-2-oxoethyl (3,4-dimethoxyphenyl)acetate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0066

2-(8-fluoro-3,4-dihydroquinolin-1(2H)-yl)-N-(quinolin-5-yl)acetamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0045

2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 2-methylquinoline-4-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0053

2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 3-(cyclopropylsulfamoyl)thiophene-2-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0015 - 0.0034

2-oxo-2-(3-sulfamoylanilino)ethyl 2-(furan-2-yl)quinoline-4-carboxylate

show

0.0034

2-oxo-2-[(quinolin-5-yl)amino]ethyl 1-(5-carbamoylpyridin-2-yl)piperidine-4-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.00093

2-phenyl-7-(quinoline-6-carbonyl)-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0007

2-[(3,5-dichloropyridin-2-yl)amino]-2-oxoethyl 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0029

2-[(4-acetylbenzene-1-sulfonyl)amino]thiophene-3-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.00053

2-[(5-chloropyridin-2-yl)amino]-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0014

2-[2-(1-methyl-2-phenyl-2,3-dihydro-1H-indol-3-yl)-2-oxoethyl]-1,3-dioxo-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carbonitrile

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0019

2-[2-(3-chlorophenoxy)acetamido]thiophene-3-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0025

2-[2-(4-oxocinnolin-1(4H)-yl)acetamido]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0027

2-[3-(benzenesulfonyl)-7-methyl-4-oxo-1,8-naphthyridin-1(4H)-yl]-N-methyl-N-phenylacetamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.002

2-[5-[2-(methylamino)-1,3-thiazol-4-yl]thiophen-2-yl]acetamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.00031

3-(1H-pyrrol-1-yl)-N-[4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl]benzamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0017

3-(4-methoxyphenyl)-7-[(1H-pyrrol-2-yl)methyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0087

3-oxo-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0091

3-oxo-N-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0097

3-oxo-N-[[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0018

4-((4-azidobenzyl)oxy)-N-(4-((octylamino)methyl)benzyl)thieno-[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.000085

4-oxo-N-(4-((pentylamino)methyl)benzyl)-3,4-dihydrothieno-[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.0011

4-oxo-N-(4-(piperidin-1-ylmethyl)benzyl)-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.0019

4-[(tetrazolo[1,5-b]pyridazin-6-yl)amino]benzamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0056

4-[3-(8-hydroxyimidazo[1,2-a]pyridin-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl]benzene-1-sulfonamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0029

4-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]thiomorpholine

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0025

5,7-dimethyl-N-(4H-1,2,4-triazol-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.00049

5-(5-methylthiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0036

5-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-2-(3-fluorophenyl)-7-methyl-3-(1H-pyrrol-1-yl)-2,3,3a,5-tetrahydro-4H-pyrazolo[3,4-d]pyridazin-4-one

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.011

6-(2-[[(furan-2-yl)methyl]amino]-1,3-thiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0054

6-[5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl][1,2,4]triazolo[4,3-a]pyridine

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.006

ethyl 4-[(3-cyano-6,7-dimethoxyquinolin-4-yl)amino]benzoate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0028

N-(2-methoxy-5-methylphenyl)-N'-[1,2,4]triazolo[4,3-a]pyridin-3-ylurea

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.005

N-(3,4-dimethylphenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0047

N-(3-acetylphenyl)-N2-[5-chloro-2-(pyrrolidin-1-yl)phenyl]glycinamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0016

N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloropyridine-2-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.006

N-(3-carbamoylthiophen-2-yl)-2-(pyridin-4-yl)quinoline-4-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0021

N-(3-cyanothiophen-2-yl)-2-(furan-2-yl)quinoline-4-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.00072

N-(4-((((3s,5s,7s)-adamantan-1-yl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00045

N-(4-(((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)methyl)-benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00021

N-(4-(((2-(2-ethoxyethoxy)ethyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00011

N-(4-(((2-(2-hydroxyethoxy)ethyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00008

N-(4-(((4-aminobutyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide dihydrochloride

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.0013

N-(4-(((5-(1,5-dihydroxy-4-oxo-1,4-dihydropyridine-2-carboxamido)pentyl)amino) methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00011

N-(4-(((5-aminopentyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00014

N-(4-(((7-aminohexyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.0007

N-(4-((1,5-dihydroxy-4-oxo-1,4-dihydropyridine-2-carboxamido)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]-pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.0022

N-(4-((benzyl(ethyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.0022

N-(4-((benzyl(hexyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.012

N-(4-((benzyl(octyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00013

N-(4-((benzylamino)methyl)benzyl)-4-oxo-3,4-dihydrothieno-[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00015

N-(4-((butylamino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00049

N-(4-((cyclohexyl(ethyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00079

N-(4-((cyclohexylamino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.000025

N-(4-((decylamino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00073

N-(4-((diethylamino)methyl)benzyl)-4-oxo-3,4-dihydrothieno-[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00038

N-(4-((dodecylamino)methyl)benzyl)-4-oxo-3,4-dihydrothieno-[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.00037

N-(4-((ethyl(octyl)amino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.000024

N-(4-((octylamino)methyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.003

N-(4-(morpholinomethyl)benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

0.0013

N-([1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-4-yl]methyl)-1H-indole-2-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.01

N-([2-[(morpholin-4-yl)methyl]phenyl]methyl)-2-(thiophene-2-carbonyl)benzamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.00018

N-([4-[(4-aminopiperidin-1-yl)methyl]phenyl]methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Pseudomonas aeruginosa

-

pH 8.0, 37°C

-

0.0043

N-methyl-1-[2-([[2-(pyridin-3-yl)quinazolin-4-yl]amino]methyl)phenyl]methanesulfonamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0062

N-methyl-N-[(oxan-4-yl)methyl]-2-(thiophen-3-yl)acetamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0013

N-methyl-N-[[2-(pyrrolidin-1-yl)phenyl]methyl]-3-(1H-pyrrol-1-yl)benzamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0039

N-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]quinoline-6-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0029

N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-1H-indole-2-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.012

N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-2-(thiophen-2-yl)acetamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0068

N-[2-oxo-2-[(1,3,5-trimethyl-4,5-dihydro-1H-pyrazol-4-yl)amino]ethyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0087

N-[3-(pyridin-4-yl)-1,2-oxazol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0021

N-[3-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]quinoline-2-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.014

N-[3-[(3-fluoro-4-methylphenyl)carbamoyl]phenyl]-1-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperidine-3-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0019

N-[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)propanamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0031

N-[4-chloro-3-(pyrrolidine-1-sulfonyl)phenyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.001

N-[[4-(piperidine-1-carbonyl)phenyl]methyl]-2-(thiophene-2-carbonyl)benzamide

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0083

sinefungin

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0091

suramin

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0059

[4-(hydroxymethyl)-2,8-diazaspiro[4.5]decan-2-yl][1-(4-methoxyphenyl)cyclohexyl]methanone

Pseudomonas aeruginosa

pH and temperature not specified in the publication

0.0053

[5-(furan-2-yl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]methyl pyrazine-2-carboxylate

Pseudomonas aeruginosa

pH and temperature not specified in the publication

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)