2.1.1.203: tRNA (cytosine34-C5)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (cytosine34-C5)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.203
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2.1.1.203
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5-methylcytosine
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anticodon
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homocysteine
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wobble
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ualcan
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5-formylcytosine
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biallelic
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omnibus
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shrinkage
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hyperhomocysteinemia
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encephalomyopathy
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nsun2-mediated
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epitranscriptome
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early-onset
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medicine
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pharmacology
- 2.1.1.203
- 5-methylcytosine
-
anticodon
- homocysteine
-
wobble
-
ualcan
- 5-formylcytosine
-
biallelic
-
omnibus
-
shrinkage
-
hyperhomocysteinemia
- encephalomyopathy
-
nsun2-mediated
-
epitranscriptome
-
early-onset
- medicine
- pharmacology
Reaction
Synonyms
5-methylcytosine RNA methyltransferase, cytosine-5 RNA methyltransferase, cytosine-5 tRNA methyltransferase, DnmA, EC 2.1.1.29, hTrm4, M5C RNA methyltransferase, NOP2/Sun domain family member 2, NSUN2, NSUN3, NSUN3 methylase, PMT1, RCMT, RNA:m5C methyltransferase, SAKI, substrate of AIM-1/Aurora kinase B
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Natural Substrates Products
Natural Substrates Products on EC 2.1.1.203 - tRNA (cytosine34-C5)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + cytidine34 in mitochondrial tRNA
S-adenosyl-L-homocysteine + 5-methylcytidine34 in mitochondrial tRNA
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S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor
S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet(AUA) precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet(AUA) precursor
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?
S-adenosyl-L-methionine + cytosine34 in tRNA
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
specific modification of cytosine34 in the intron-containing yeast pre-tRNALeu(CAA)
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?
S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
S-adenosyl-L-methionine + cytosine34 in tRNALeu(CAG) precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNALeu(CAG) precursor
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?
S-adenosyl-L-methionine + microRNA 125b
S-adenosyl-L-homocysteine + ?
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the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo
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S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor
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S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor
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?
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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?
S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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?
S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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?
S-adenosyl-L-methionine + cytosine34 in tRNA precursor
S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
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levels of m5C changes site-specifically and dynamically in response to oxidative stress. All individual m5C sites showing significantly different methylation levels in NSUN2-rescued cells after 2 or 4 hours of stress. Methylation levels within the same tRNA molecule are independent from each other
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additional information
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the Nsun2 fabricate 5-methylcytosine (m5C) in RNA molecules utilizing a dual-cysteine catalytic mechanism
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additional information
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NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis
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