2.1.1.17: phosphatidylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.17
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2.1.1.17
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phosphatidylcholine
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choline
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homocysteine
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cytidylyltransferase
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cdp-choline
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betaine
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s-adenosylhomocysteine
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ctp:phosphocholine
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cdp-diacylglycerol
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phosphatidyl-n,n-dimethylethanolamine
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phosphatidyl-n-monomethylethanolamine
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choline-deficient
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transmethylation
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n-methyltransferases
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kennedy
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adomet
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vance
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phosphatidylmonomethylethanolamine
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medicine
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ptdcho
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analysis
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phosphatidyldimethylethanolamine
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mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
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choline-supplemented
- 2.1.1.17
- phosphatidylcholine
- choline
- homocysteine
- cytidylyltransferase
- cdp-choline
- betaine
- s-adenosylhomocysteine
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ctp:phosphocholine
- cdp-diacylglycerol
- phosphatidyl-n,n-dimethylethanolamine
- phosphatidyl-n-monomethylethanolamine
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choline-deficient
-
transmethylation
- n-methyltransferases
-
kennedy
- adomet
-
vance
- phosphatidylmonomethylethanolamine
- medicine
-
ptdcho
- analysis
- phosphatidyldimethylethanolamine
- mthfd1
-
remethylation
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cholinephosphotransferase
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adohcy
-
choline-supplemented
Reaction
Synonyms
lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3
ECTree
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Inhibitors
Inhibitors on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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S-adenosylhomocysteine
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competitive with respect to S-adenosylmethionine
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phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site
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additional information
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phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site
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additional information
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the cell toxicity for Spodoptera frugiperda (SF-9) insect cells of the phosphatidylethanolamine N-methyltransferase preparation dissapears, when the phosphatidylethanolamine N-methyltransferase preparation is treated with 100 mg Bio-Beads SM-2 + 10 mg Butyl Toyopearl or 100 g Bio-Beads SM-2 + 10 mg CM Toyopearl.; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent Bio-Beads SM-2 decreases the phosphatidylethanolamine N-methyltransferase activity to: 24.1% with 50 mg and 28.6% with 100 mg. Addition of 1% Trition X-100 restores the activity to 90% in the experiment with 100 mg Bio-Beads SM-2.; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent Butyl Toyopearl decreases the phosphatidylethanolamine N-methyltransferase activity to: 0.2% with 10 mg; treatment of the phosphatidylethanolamine N-methyltransferase preparation with the adsorbent CM Toyopearl decreases the phosphatidylethanolamine N-methyltransferase activity to: 0.4% with 10 mg
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