2.1.1.167: 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.167
-
2.1.1.167
-
rrnas
-
nucleolar
-
2'-o-ribose
-
pre-ribosomal
-
coimmunoprecipitation
-
cold-sensitive
-
methyltransferases
- 2.1.1.167
- rrnas
-
nucleolar
-
2'-o-ribose
-
pre-ribosomal
-
coimmunoprecipitation
-
cold-sensitive
- methyltransferases
Reaction
Synonyms
Spb1p
ECTree
Advanced search results
General Information
General Information on EC 2.1.1.167 - 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
a point mutation in the Ado-Met binding site of Spb1p affects cell growth but does not abolish methylation of U2918. When this mutation is combined with disruption of snR52 cell growth is severely impaired and U2918 is no longer methylated. In vitro, Spb1p is able to methylate U2918 on 60S subunits. For this methylation two mechanisms coexist: a site-specific methyltransferase (Spb1p) and a snoRNA-dependent mechanism
malfunction
in an spb1-2 strain grown at the restrictive temperature, processing of the 27S prerRNA into mature 25S rRNA and 5.8S is completely abolished and production of mature 18S is reduced, while the abnormal 23S species is accumulated