2.1.1.137: arsenite methyltransferase

This is an abbreviated version!
For detailed information about arsenite methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

AdoMet:arsenic(III) methyltransferase, arsenic (+3 oxidation state) methyltransferase, arsenic (+3 oxidation state)-methyltransferase, arsenic (+3) methyltransferase, arsenic (III) methyltransferase, arsenic (III) S-adenosylmethionine methyltransferase, arsenic methyltransferase Cyt19, arsenic(III) methyltransferase, arsenite (+3 oxidation state) methyltransferase, arsenite methyltransferase, arsenite S-adenosylmethionine methyltransferase, ArsM, ArsM protein, ArsM7B, As(III) methyltransferase, As(III) S-adenosylmethionine methyltransferase, As(III) SAM methyltransferase, AS3MT, AsIII S-adenosylmethionine methyltransferase, Cyr19, Cyt19, EC 2.1.1.138, hAS3MT, methylarsonite methyltransferase, N6AMT1, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, S-adenosylmethionine dependent arsenic methyltransferase, [As(III)] methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.137 arsenite methyltransferase

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Results	in table
24	Activating Compound
213	AA Sequence
2	Application
1	CAS Registry Number
38	Cloned(Commentary)
19	Cofactor
4	Crystallization (Commentary)
114	Disease/ Diagnostics
3	Expression
10	General Information
17	Inhibitors
2	Ki Value [mM]
41	KM Value [mM]
8	Localization
12	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
96	Organism
2	PDB ID
11	pH Optimum
2	pH Range
55	Protein Variants
17	Purification (Commentary)
15	Reaction
1	Reaction Type
81	Reference
62	Source Tissue
11	Specific Activity [micromol/min/mg]
93	Substrates and Products (Substrate)
14	Subunits
114	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.137 - arsenite methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

26 entries

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

11 entries

additional information

?

-

17 entries

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Clostridium sp.

A0A0D3MJQ5

-

733887

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Clostridium sp. BXM

A0A0D3MJQ5

-

733887

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Cricetinae

-

-

485148

-

485148

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Cyanidioschyzon sp.

C0JV69

-

733333

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

Q9HBK9

-

701300, 733425

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

-

-

733425

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

Q9HBK9

-

733451, 733865

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

-

-

733865

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

Q9HBK9

-

734199, 735126

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

-

-

735126

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

Q9HBK9

-

735309

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

-

AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans

674763

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

-

hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells

673066

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Homo sapiens

Q9HBK9

As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview

697642

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Macaca mulatta

-

-

485151

-

485151

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Methanosarcina acetivorans

-

-

733740

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Mus musculus

-

-

485149

-

485149

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Mus musculus

Q91WU5

-

695519

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Oryctolagus cuniculus

-

-

485151

-

485151

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Oryctolagus cuniculus

-

-

485152

-

485152

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Pseudomonas alcaligenes

U2ZU49

-

733175

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Pseudomonas alcaligenes NBRC 14159

U2ZU49

-

733175

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Rhodopseudomonas palustris

-

-

733950

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Rhodopseudomonas palustris

-

methylation of environmental arsenic by conversion to soluble and gaseous methylated species is a detoxifying process that may contribute to global cycling of arsenic

676841

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Rhodopseudomonas palustris CGA009

-

methylation of environmental arsenic by conversion to soluble and gaseous methylated species is a detoxifying process that may contribute to global cycling of arsenic

676841

-

-

?

S-adenosyl-L-methionine + arsenite

S-adenosyl-L-homocysteine + methylarsonate

Tetrahymena pyriformis

-

-

733203

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Clostridium sp.

A0A0D3MJQ5

-

733887

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Clostridium sp. BXM

A0A0D3MJQ5

-

733887

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Cyanidioschyzon sp.

C0JV69

-

733333

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Homo sapiens

Q9HBK9

-

733451, 733865

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Homo sapiens

-

-

733865

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Homo sapiens

Q9HBK9

-

734199, 735309

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Methanosarcina acetivorans

-

-

733740

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Pseudomonas alcaligenes

U2ZU49

-

733175

the enzyme also produces also produces dimethylarsine and trimethylarsine gases as by-products

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Pseudomonas alcaligenes NBRC 14159

U2ZU49

-

733175

the enzyme also produces also produces dimethylarsine and trimethylarsine gases as by-products

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Rhodopseudomonas palustris

-

-

733950

-

-

?

S-adenosyl-L-methionine + methylarsonite

S-adenosyl-L-homocysteine + dimethylarsinate

Tetrahymena pyriformis

-

-

733203

-

-

?

additional information

?

-

Bos taurus

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Bos taurus

Q58DQ0

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Ciona intestinalis

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Gallus gallus

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Homo sapiens

Q9HBK9

As3MT methylates inorganic arsenic and its metabolites

697642

-

-

?

additional information

?

-

Homo sapiens

Q9HBK9

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Homo sapiens

Q9HBK9

genetic susceptibility to arsenic toxicity in Asian is different from Africans and Caucasians, overview

700331

-

-

?

additional information

?

-

Homo sapiens

-

genetic susceptibility to arsenic toxicity in Asian is different from Africans and Caucasians, overview

700331

-

-

?

additional information

?

-

Mus musculus

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Oncorhynchus mykiss

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Pan troglodytes

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Rattus norvegicus

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Rattus norvegicus

Q8VHT6

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Rhodopseudomonas palustris

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Rhodopseudomonas palustris

-

the enzyme is responsible for the removal of arsenic as the volatile arsines from the bacteria producing trimethylarsine via successive methylation

697651

-

-

?

additional information

?

-

Strongylocentrotus purpuratus

-

enzyme evolutionary analysis

673463

-

-

?

additional information

?

-

Tetrahymena pyriformis

-

besides methylarsonate and dimethylarsinate, the enzyme also produces trimethylarsenite and dimethylarsine gases

733203

-

-

?