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1.8.3.7: formylglycine-generating enzyme

This is an abbreviated version!
For detailed information about formylglycine-generating enzyme, go to the full flat file.

Word Map on EC 1.8.3.7

Reaction

a [sulfatase]-L-cysteine
+
O2
 + 2 a thiol =
a [sulfatase]-3-oxo-L-alanine
 +
hydrogen sulfide
 +
a disulfide
 +
H2O

Synonyms

AtsB, C-alpha-formylglycine-generating enzyme 1, Calpha-formylglycine-generating enzyme, Calpha-formylglycine-generating enzyme 1, FGE, FGly-generating enzyme, formylglycine generating enzyme, sulfatase-modifying factor 1, SUMF1

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.3 With oxygen as acceptor
                1.8.3.7 formylglycine-generating enzyme

Substrates Products

Substrates Products on EC 1.8.3.7 - formylglycine-generating enzyme

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a [sulfatase]-L-cysteine + O(2) + a thiol
a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
show the reaction diagram
a [sulfatase]-L-cysteine + O2 + 2 a thiol
a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
show the reaction diagram
a [sulfatase]-L-cysteine + O2 + a thiol
a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
show the reaction diagram
Abz-ATTPLCGPSRASILSGR + O2 + reduced dithiothreitol
? + hydrogen sulfide + oxidized dithiothreitol + H2O
show the reaction diagram
Abz-SAL-3-oxo-L-Ala-SPTRA-NH2 + O2 + hydrogen sulfide + oxidized dithiothreitol
?
show the reaction diagram
-
-
-
-
?
Abz-SALCSPTRA-NH2 + O2 + reduced dithiothreitol
Abz-SAL-3-oxo-L-Ala-SPTRA-NH2 + H2O + hydrogen sulfide + oxidized dithiothreitol
show the reaction diagram
Ac-AL-3-oxo-L-Ala-TPSRGSLFTGR-NH2 + hydrogen sulfide + oxidized dithiothreitol + H2O
?
show the reaction diagram
Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + a thiol
?
show the reaction diagram
Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + reduced dithiothreitol
? + hydrogen sulfide + oxidized dithiothreitol + H2O
show the reaction diagram
accepts the sequence CTPSR. The human enzyme strictly converts proline-containing aldehyde tags, either in vivo or in vitro, whereas in the presence of copper, the enzyme fom Streptomyces coelicolor and Mycobacterium tuberculosis tolerate proline-to-alanine substitutions in the core motif
-
-
?
Ac-LCSPSRGSLFTGR-NH2 + O2 + reduced dithiothreitol
Ac-L-3-oxo-L-Ala-SPSRGSLFTGR-NH2 + H2O + hydrogen sulfide + oxidized dithiothreitol
show the reaction diagram
AC-MTDFYVPVSLCTPSRAALLTGRS-amide + O2 + reduced dithiothreitol
AC-MTDFYVPVSL-3-oxo-Ala-TPSRAALLTGRS-amide + H2O + hydrogen sulfide + oxidized dithiothreitol
show the reaction diagram
-
-
-
-
?
acetyl-MTDFYVPVSLCTPSRAALLTGRS-amide + O2 + dithiothreitol
?
show the reaction diagram
-
-
-
?
acetyl-Tyr-Tyr-Thr-Ser-Pro-Met-3-oxo-Ala-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn-COOH + O2 + dithionite
?
show the reaction diagram
LCSPSRGSLFTGR + O2 + dithiothreitol
leucyl-formylglycyl-SPSRGSLFTGR + ?
show the reaction diagram
LCSPSRGSLFTGR + O2 + dithiothreitol
leucyl-formylglycyl-SPSRGSLFTGR + sulfide + oxidized dithiothreitol + H2O
show the reaction diagram
NH2-Tyr-Tyr-Thr-Ser-Pro-Met-3-oxo-Ala-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn-COOH + O2 + dithionite
?
show the reaction diagram
NH2-Tyr-Tyr-Thr-Ser-Pro-Met-Cys-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn-COOH + O2 + dithionite
?
show the reaction diagram
[arylsulfatase A]-L-cysteine69 + O2 + reduced acceptor
[arylsulfatase A]-Calpha-formylglycine69 + hydrogen sulfide + acceptor
show the reaction diagram
-
-
-
-
?
additional information
?
-