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1.3.1.102: 2-alkenal reductase (NADP+)

This is an abbreviated version!
For detailed information about 2-alkenal reductase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.102

Reaction

an n-alkanal
+
NADP+
=
an alk-2-enal
+
NADPH
+
H+

Synonyms

2-alkenal reductase, 2-alkenal reductase (NADP+-dependent), AER, alkenal double bond reductase, allyl-ADH, allyl-ADH1, allyl-ADH2, allyl-alcohol dehydrogenase, AOR, AtAOR, chloroplastic alkenal/one oxidoreductase, double-bond reductase 1, double-bond reductase 2, NADPH-dependent alkenal/one oxidoreductase, NtDBR, NtRed-1, PaDBR1, PaDBR2

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.102 2-alkenal reductase (NADP+)

Engineering

Engineering on EC 1.3.1.102 - 2-alkenal reductase (NADP+)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C56A
site-directed mutagenesis, the mutant shows altered substrate specificity with cinnamoyl aldehydes compared to wild-type enzyme
C56F
site-directed mutagenesis, the mutant shows altered substrate specificity and increased activity with cinnamoyl aldehydes compared to wild-type enzyme
C56S
site-directed mutagenesis, the mutant shows altered substrate specificity with cinnamoyl aldehydes compared to wild-type enzyme
C56V
site-directed mutagenesis, the mutant shows altered substrate specificity with cinnamoyl aldehydes compared to wild-type enzyme
C56Y
site-directed mutagenesis, the mutation turns the substrate selectivity and catalytic efficiency of isozyme PaDBR1 indistinguishable from those of isozyme PaDBR2, Docking arrangement of PaDBR1C56Y with NADP+/p-coumaryl aldehyde, overview. Increased activity compared to wild-type enzyme
additional information