1.14.19.77: plasmanylethanolamine desaturase
This is an abbreviated version!
For detailed information about plasmanylethanolamine desaturase, go to the full flat file.
Word Map on EC 1.14.19.77
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1.14.19.77
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plasmalogens
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ether
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phospholipids
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vinyl
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plasmalogen-deficient
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macrophage-like
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zoeller
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arachidonic
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orphan
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glycerophospholipids
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desaturases
- 1.14.19.77
- plasmalogens
- ether
- phospholipids
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vinyl
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plasmalogen-deficient
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macrophage-like
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zoeller
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arachidonic
-
orphan
- glycerophospholipids
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desaturases
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 + 2 H2O
Synonyms
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase, alkylacylglycero-phosphorylethanolamine dehydrogenase, alkylacylglycerophosphoethanolamine desaturase, CarF, dehydrogenase, alkyl-acylglycerophosphorylethanolamine, DELTA1'-alkyl desaturase, DELTA1'-desaturase, desaturase, alkylacylglycerophosphorylethanolamine, EC 1.14.99.19, PEDS, plasmanyl D1'-desaturase, plasmanyl DELTA1'-desaturase, plasmanyl desaturase, plasmanylethanolamine D1-desaturase, TMEM189
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Substrates Products
Substrates Products on EC 1.14.19.77 - plasmanylethanolamine desaturase
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REACTION DIAGRAM
1-hexadecyl-2-acyl glycero-3-phosphoethanolamine + NADH + O2
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in situ in the microsomes via acylation of 1-hexadecyl-glycero-3-phosphoethanolamine
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?
1-O-hexadecyl-rac-glycero-3-phosphorylethanolamine + NADPH + O2 + H+
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good substrate
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?
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+
a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
alkyl ether plasmanylethanolamine + NADPH + O2
vinyl ether phosphatidylethanolamine + NADP+ + H2O
iso15:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
iso15:0-dimethylacetal + NADP+ + H2O
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-
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?
iso16:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
iso16:0-dimethylacetal + NADP+ + H2O
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-
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?
iso18:0-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
iso18:0-dimethylacetal + NADP+ + H2O
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-
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?
iso18:1-O-alkylglycerol-bis-trimethylsilyl ether + NADPH + O2
iso18:1-dimethylacetal + NADP+ + H2O
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
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i.e. plasmanylethanolamine
i.e. plasmenylethanolamine
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + reduced cytochrome b5 + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized cytochrome b5 + 2 H2O
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i.e. plasmanylethanolamine, the reaction involves reaction involving cytochrome b5 reductase, molecular oxygen and a reduction equivalent
i.e. plasmenylethanolamine
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?
[1-3H ethanolamine]-1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + NADH + O2 + H+
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a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
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a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+
a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O
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vinyl ether phosphatidylethanolamine + NADP+ + H2O
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alkyl ether plasmanylethanolamine + NADPH + O2
vinyl ether phosphatidylethanolamine + NADP+ + H2O
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?
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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-
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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-
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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-
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?
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + electron donor + O2
O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + oxidized electron donor + H2O
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generated in situ by microsomal acylation of alkyllyso-glycero-3-phosphoethanolamine, better substrate than when it is added exogenously
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the enzyme converts plasmanylethanolamine into plasmenylethanolamine by introducing a vinyl double bound. It requires cytochrome b5, molecular oxygen and either NADPH or NADH as cofactors for functional catalysis. Plasmanylcholines are no substrates for plasmanylethanolamine desaturase
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additional information
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no substrates: O-3-alkyl-2-acyl-sn-glycero-1-phosphoethanolamine, octadecylglycerol, octadecanal, octadecanol, stearic acid
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additional information
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highly specific with regard to chain length of saturated alkyl moieties of alkylacylglycerophosphoethanolamines
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additional information
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high degree of substrate specificity, no substrate is O-1-alkyl-ethanediol-2-phosphoethanolamine
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additional information
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no selectivity of the desaturase for specific acyl chains
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additional information
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highly specific with regard to chain length of saturated alkyl moieties of alkylacylglycerophosphoethanolamines
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