1.14.19.57: 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase
This is an abbreviated version!
For detailed information about 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase, go to the full flat file.
Reaction
+ 3 FADH2 + 3 bromide + 3 O2 = + 3 FAD + 6 H2O
Synonyms
bmp2
ECTree
Advanced search results
Results | in table |
---|---|
1 | Cloned(Commentary) |
2 | Cofactor |
2 | General Information |
2 | Organism |
4 | Reaction |
2 | Reference |
4 | Substrates and Products (Substrate) |
1 | Synonyms |
1 | Systematic Name |
Systematic Name
Systematic Name on EC 1.14.19.57 - 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
1H-pyrrole-2-carbonyl-[peptidyl-carrier protein]:FADH2 oxidoreductase (brominating)
The enzyme, characterized from marine bacteria of the Pseudoalteromonas genus, belongs to a family of FAD-dependent halogenases that act on acyl-carrier protein-tethered substrates. It catalyses three successive rounds of bromination. While the order has not been verified, it is believed to resemble that of EC 1.14.19.56, S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] chlorinase, due to significant sequence homology. Reduced FAD is provided in situ by a dedicated reductase and diffuses into the active site, where it reacts with the oxygen and bromide ion, resulting in formation of a bromoamine intermediate on a catalytic lysine side chain, and the eventual transfer of the bromide to the substrate. The enzyme from Pseudoalteromonas luteoviolacea 2ta16 is specific for bromide and does not accept chloride.