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1.14.19.45: sn-1 oleoyl-lipid 12-desaturase

This is an abbreviated version!
For detailed information about sn-1 oleoyl-lipid 12-desaturase, go to the full flat file.

Word Map on EC 1.14.19.45

Reaction

a 1-oleoyl-2-acyl-[glycerolipid]
+ 2 reduced ferredoxin [iron-sulfur] cluster +
O2
+ 2 H+ =
a 1-linoleoyl-2-acyl-[glycerolipid]
+ 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O

Synonyms

acyl-lipid DELTA12 desaturase, bifunctional DELTA12/DELTA15-fatty acid desaturase, CpFAD2, CsFAD2, DELTA(12) fatty acid desaturase, DELTA12 acyl-lipid desaturase, DELTA12 desaturase, DELTA12 fatty acid desaturase, DELTA12-acyl-lipid desaturase, DELTA12-desaturase, DELTA12-fatty acid desaturase, DELTA5 Des, DELTA5 desaturase, DesA, DesA desaturase, FAD2, FAD2-1, FAD2-2, FAD2-3, More, oleate DELTA12desaturase, RKD12, TcasZ12, YALI0B10153g

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.45 sn-1 oleoyl-lipid 12-desaturase

Expression

Expression on EC 1.14.19.45 - sn-1 oleoyl-lipid 12-desaturase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a culture temperature downshift from 28°C to 15°C induces the enzyme
desA expression is repressed during the lag phase at low temperature in presence of unsaturated fatty acids, in a CasK/R(two-component system)-independent manner
the promoter activity of the desA gene encoding the DELTA5 fatty acid desaturase, providing unsaturated fatty acids required for low temperature adaptation, is repressed in the casK/R mutant grown at 12°C versus 37°C. The CasK/R two-component system activates desA expression during Bacillus cereus growth at low temperature, allowing an optimal unsaturation of the fatty acids. In contrast, desA expression is repressed during the lag phase at low temperature in presence of unsaturated fatty acids, in a CasK/R-independent manner
the transcription of FAD2 is upregulated in response to n-alkanes and fatty acids, and to lower temperature. The transcript levels of FAD2 are higher in the cells cultured in the medium containing n-dodecane, n-octadecane, or oleic acid at 30°C, when compared with that in the medium containing glucose. The transcript level of FAD2 is higher at 12°C, compared with that at 30°C
the two-component system CasK/R activates desA expression during Bacillis cereus growth at low temperature, allowing an optimal unsaturation of the fatty acids