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(3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-ol
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specific
(3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol
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specific
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
(3S,20S)-20-N-ethylcarbamoylpregn-7-en-3beta-ol
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(3S,20S)-20-N-ethylcarbamoylpregn-7-en-3beta-yl acetate
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(3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-ol
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specific
(3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
(3S,20S)-20-N-propylcarbamoylpregn-7-en-3beta-ol
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(3S,20S)-20-N-propylcarbamoylpregn-7-en-3beta-yl acetate
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(3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-ol
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specific
(3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol
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average content of 7-dehydrocholesterol in human primary hepatocytes after 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol treatment is, 34.16 times higher than that in nontreated cells, indicating that DHCR7 is the major target (minor targets are human sterol DELTA14-reductase, sterol DELTA24-reductase, and sterol C5-desaturase). In vitro kinetic measurements show that the half-life of 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol is at least 4.3 h. 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol does not induce CYP3A4 mRNA nor enzyme activity
4,5-dihydroxy-1,3-benzene-disulfonic acid
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trivial name tiron, 0.5 mM, 80% inhibition
alpha-(2,4-dichlorophenyl)-alpha-phenyl-5-pyrimidine methanol
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trivial name triarimol, weak inhibition
anti-cytochrome b5 antibodies
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0.5 mg/mg protein. 36% inhibition
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bathophenanthroline
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0.5 mM, 71% inhibition
CYC (cyctochrome c)
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dithiothreitol
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1.0 mM, 55% inhibition
lathosterol side chain amides
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synthesis and compound screening, influence of different sterol amides on inhibition of the enzyme, overview, lathosterol-derived amides with larger substituents, e.g. butyl, isobutyl, tert-butyl, pentyl, at the amide nitrogen are selective inhibitors of lathosterol oxidase, overview
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menadione
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32% residual actitivty at 0.05 mM
Salicylhydroxamic acid
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salicylic hydroxamic acid
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Tiron
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21% residual activity at 1 mM
Triarimol
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weak inhibition
1,10-phenanthroline
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0.5 mM, 74% inhibition
CN-
0.003 mM, 50% inhibition of recombinant enzyme
CN-
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0.5 mM, 95% inhibition
CN-
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0.003-0015 mM, 50% inhibition
cyanide
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cyanide
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complete inhibition at 5 mM
additional information
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cytotoxicity and inhibitor potencies for inhibition of total cholesterol biosynthesis, overview
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additional information
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the enzyme is not affected by N-ethylmaleimide and dithiothreitol
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additional information
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not inhibited by CO
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additional information
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not inhibited by CO
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