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1.14.14.79: docosahexaenoic acid omega-hydroxylase

This is an abbreviated version!
For detailed information about docosahexaenoic acid omega-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.79

Reaction

docosahexaenoate
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
22-hydroxydocosahexaenoate
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP4F3B, CYP4V2, docosahexaenoic acid omega-hydroxylase, EC 1.14.13.199

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.79 docosahexaenoic acid omega-hydroxylase

Systematic Name

Systematic Name on EC 1.14.14.79 - docosahexaenoic acid omega-hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
docosahexaenoate,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate forming)
A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.