1.14.14.138: lithocholate 6beta-hydroxylase
This is an abbreviated version!
For detailed information about lithocholate 6beta-hydroxylase, go to the full flat file.
Word Map on EC 1.14.14.138
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1.14.14.138
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testosterone
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ketoconazole
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6beta-hydroxylation
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7-ethoxyresorufin
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bufuralol
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o-dealkylase
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chlorzoxazone
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troleandomycin
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cyp3a-dependent
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dextromethorphan
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4'-hydroxylase
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cyp3a-mediated
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cdna-expressed
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triacetyloleandomycin
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7-pentoxyresorufin
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2alpha-hydroxylase
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s-mephenytoin
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7alpha
- 1.14.14.138
- testosterone
- ketoconazole
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6beta-hydroxylation
- 7-ethoxyresorufin
- bufuralol
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o-dealkylase
- chlorzoxazone
- troleandomycin
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cyp3a-dependent
- dextromethorphan
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4'-hydroxylase
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cyp3a-mediated
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cdna-expressed
- triacetyloleandomycin
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7-pentoxyresorufin
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2alpha-hydroxylase
- s-mephenytoin
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7alpha
Reaction
Synonyms
3A10/lithocholic acid 6beta-hydroxylase, 6beta-hydroxylase, CYP3A10, cytochrome P450 3A10/lithocholic acid, cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase, EC 1.14.13.94, lithocholate 6beta-monooxygenase, lithocholic acid 6beta-hydroxylase
ECTree
1.14.14.138 lithocholate 6beta-hydroxylaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.14.14.138 - lithocholate 6beta-hydroxylase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
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hydroxylations of bile acids by reconstituted systems from rat liver microsomes
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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a STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase gene expression by growth hormone
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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the male-specific P450 catalyzes the reaction. The pattern of growth hormone secretion is directly responsible for male-specific expression of this gene. STAT 5a and STAT 5b mediates GH-dependent regulation of CYP3A10/6beta-hydroxylase promoter activity
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?
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
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?
