1.14.14.133: 1,8-cineole 2-endo-monooxygenase
This is an abbreviated version!
For detailed information about 1,8-cineole 2-endo-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.133
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1.14.14.133
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p450cam
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heme
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monooxygenases
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h-bonding
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citrobacter
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monoterpenes
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fmn
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substrate-bound
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fmn-containing
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braakii
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substrate-free
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monoterpenoid
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sesquiterpene
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s-oxidations
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bicyclic
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terpene
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ferryl
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low-spin
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regioselective
- 1.14.14.133
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p450cam
- heme
- monooxygenases
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h-bonding
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citrobacter
- monoterpenes
- fmn
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substrate-bound
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fmn-containing
- braakii
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substrate-free
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monoterpenoid
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sesquiterpene
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s-oxidations
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bicyclic
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terpene
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ferryl
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low-spin
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regioselective
Reaction
Synonyms
CinA, CYP176A, CYP176A1, EC 1.14.13.156, P450cin
ECTree
1.14.14.133 1,8-cineole 2-endo-monooxygenaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.14.14.133 - 1,8-cineole 2-endo-monooxygenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,8-cineole + [reduced NADPH-hemoprotein reductase] + O2
2-endo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
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additional information
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P450cin catalyzes the stereoselective hydoxylation of 1,8-cineole to 2beta-hydroxy-1,8-cineole. The two electrons necessary for the conversion of 1,8-cineole to 2beta-hydroxy-1,8-cineole are supplied by NADPH and transferred via a FAD-containing cindoxin reductase (CinB), and an FMN-containing cindoxin (CinC) to the heme iron in the active site of P450cin (CinA). The flow of electrons in this multicomponent P450cin system is from NADPH to Fpr via CinC to CinA
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