1.11.1.8: iodide peroxidase
This is an abbreviated version!
For detailed information about iodide peroxidase, go to the full flat file.
Word Map on EC 1.11.1.8
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1.11.1.8
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thyroglobulin
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tsh
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autoimmune
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hypothyroidism
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autoantibody
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thyroxin
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women
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graves
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tpoabs
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hashimoto
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thyrotropin
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thyroid-stimulating
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pregnancy
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subclinical
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euthyroidism
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triiodothyronine
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goiter
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follicular
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overt
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thyrocytes
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anti-tpo
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antithyroid
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symporter
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organification
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trimester
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levothyroxine
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autoantigens
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thyroid-specific
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frtl-5
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guaiacol
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methimazole
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lactoperoxidase
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radioiodine
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propylthiouracil
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goitrous
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thyrotoxicosis
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antibody-negative
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multinodular
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analysis
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peroxidase-catalyzed
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hypothalamic-pituitary-thyroid
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ophthalmopathy
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gadas
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tsh-induced
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anti-thyroglobulin
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medicine
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thyroid-associated
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tsh-stimulated
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chloroperoxidase
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synthesis
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nodosum
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haloperoxidases
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thyrotoxic
- 1.11.1.8
- thyroglobulin
- tsh
- autoimmune
- hypothyroidism
- autoantibody
- thyroxin
- women
- graves
-
tpoabs
- hashimoto
- thyrotropin
-
thyroid-stimulating
- pregnancy
-
subclinical
-
euthyroidism
- triiodothyronine
- goiter
-
follicular
-
overt
- thyrocytes
-
anti-tpo
-
antithyroid
-
symporter
-
organification
-
trimester
- levothyroxine
- autoantigens
-
thyroid-specific
-
frtl-5
- guaiacol
- methimazole
- lactoperoxidase
-
radioiodine
- propylthiouracil
-
goitrous
- thyrotoxicosis
-
antibody-negative
-
multinodular
- analysis
-
peroxidase-catalyzed
-
hypothalamic-pituitary-thyroid
-
ophthalmopathy
-
gadas
-
tsh-induced
-
anti-thyroglobulin
- medicine
-
thyroid-associated
-
tsh-stimulated
- chloroperoxidase
- synthesis
- nodosum
- haloperoxidases
-
thyrotoxic
Reaction
2 iodide
+
Synonyms
bromoperoxidase, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), thyroid peroxidase, thyroperoxidase, TPO, TPOX, TPQ, tyrosine iodinase, vanadium bromoperoxidase, vBPO
ECTree
1.11.1.8 iodide peroxidaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.11.1.8 - iodide peroxidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
the molecular weight of breast TPO is slightly lower than that of thyroid TPO due to decreased glycosylation. Enzymatic activity and isoelectric point of the isomforms are comparable
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IL-1alpha/IFNgamma-induced down-regulation of thyroperoxidase is not affected by Th3 cytokines
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IL-1alpha/IFNgamma-induced down-regulation of thyroperoxidase is not affected by Th3 cytokines
TPO is expressed at gene and protein levels in endometrium and placenta, expression is mainly localized to he syncytiotrophoblasts and invasive trophoblast cells
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lesion, negative correlation between thyroperoxidase and dual oxidase H2O2-generating activities
TPO is expressed at gene and protein levels in endometrium and placenta, expression is mainly localized to glandular and luminal epithelial cells in the endometrium
additional information
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thyroid follicular cell, some TPO-specific T cells and the majority of autoantibodies in humans develop in response to TPO presented by thyroid cells, rather than to TPO released by damaged thyrocytes
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thyroid follicular cell, when thyrocytes are treated with IL-1alpha/IFNgamma thyroperoxidase expression is hindered, the viability of thyrocytes is not affected
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pathological tissue: Hashimotos thyroiditis, Graves disease, multinodular goiter, no activity in papillary carcinoma
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toxic diffuse goiter tissue samples obtained during thyroidectomies
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some TPO-specific T cells and the majority of autoantibodies in humans develop in response to TPO presented by thyroid cells, rather than to TPO released by damaged thyrocytes
the molecular weight of breast TPO is slightly lower than that of thyroid TPO due to decreased glycosylation. Enzymatic activity and isoelectric point of the isomforms are comparable
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TPO activities are similar between pre-pubertal and adult female rats. Estradiol administration does not change enzyme activity in pre-pubertal rats, while in intact adults activity is increased by low or high doses of estradiol
additional information
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recombinant TPO stably transfected into the human follicular thyroid carcinoma cell line FTC-238
additional information
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smoking is negatively associated with the presence of thyroid peroxidase autoantibody in serum
additional information
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not detected in dermal fibroblasts, HaCaT cells, and melanoma cell lines
additional information
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traces of activity in liver, kidney, heart, brain, ovary and muscle
