1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Reaction

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, HMGCoAR, HMGR, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, mvaA, NADH-dependent HMG-CoA reductase, NADH-HMGR

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.88 hydroxymethylglutaryl-CoA reductase

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Results	in table
5	Activating Compound
5616	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
49	Cofactor
5	Crystallization (Commentary)
492	Disease/ Diagnostics
2	Expression
6	General Information
9	General Stability
2	IC50 Value
38	Inhibitors
2	kcat/KM [mM/s]
10	Ki Value [mM]
59	KM Value [mM]
7	Localization
1	Metals/Ions
8	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
36	Organism
5	Pathway
32	PDB ID
18	pH Optimum
2	Posttranslational Modification
26	Protein Variants
6	Purification (Commentary)
3	Reaction
5	Reaction Type
36	Reference
1	Renatured (Commentary)
12	Source Tissue
23	Specific Activity [micromol/min/mg]
5	Storage Stability
49	Substrates and Products (Substrate)
7	Subunits
32	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

90

simvastatin acid

Burkholderia cenocepacia

B4EKH5

pH and temperature not specified in the publication

740104

0.19

simvastatin lactone

Burkholderia cenocepacia

B4EKH5

pH and temperature not specified in the publication

740104