1.1.1.61: 4-hydroxybutyrate dehydrogenase

This is an abbreviated version!
For detailed information about 4-hydroxybutyrate dehydrogenase, go to the full flat file.

Reaction

Synonyms

4HBD, gamma-hydroxybutyrate dehydrogenase, gbd, GHBDH, NAD-dependent 4-hydroxybutyrate dehydrogenase, PGN 0724 protein, succinate semialdehyde reductase, uncharacterized oxidoreductase YihU, yihU

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.61 4-hydroxybutyrate dehydrogenase

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Results	in table
1	Activating Compound
118	AA Sequence
1	Application
1	CAS Registry Number
4	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
2	General Information
1	General Stability
4	Inhibitors
4	Ki Value [mM]
18	KM Value [mM]
4	Metals/Ions
9	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
6	pH Optimum
1	pH Range
1	pI Value
4	Protein Variants
5	Purification (Commentary)
1	Reaction
3	Reaction Type
9	Reference
4	Source Tissue
4	Specific Activity [micromol/min/mg]
23	Substrates and Products (Substrate)
4	Subunits
18	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.1.1.61 - 4-hydroxybutyrate dehydrogenase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

nudix hydrolase

Cupriavidus necator

Q59104

at optimal pH 9.0, the GHBDH reaction is activated about 2fold by saturating purified nudix hydrolases, namely Bacillus methanolicus activator (ACT, UniProt: I3EA59) and Escherichia coli NudF (UniProt Q93K97) proteins. At physiological pH values of about 7.0, ACT activates by more than 3.5-fold

760643

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