2.7.1.138: ceramide kinase
This is an abbreviated version!
For detailed information about ceramide kinase, go to the full flat file.
Word Map on EC 2.7.1.138
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2.7.1.138
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ceramide-1-phosphate
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sphingolipids
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1-phosphate
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sphingosine-1-phosphate
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ceramidase
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pleckstrin
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cerkl
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medicine
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ceramide-induced
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analysis
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diagnostics
- 2.7.1.138
- ceramide-1-phosphate
- sphingolipids
- 1-phosphate
- sphingosine-1-phosphate
- ceramidase
-
pleckstrin
-
cerkl
- medicine
-
ceramide-induced
- analysis
- diagnostics
Reaction
Synonyms
acylsphingosine kinase, ceramide kinase, CERK, DCERK protein, hCERK, kinase, acylsphingosine (phosphorylating), More
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 2.7.1.138 - ceramide kinase
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lipoprotein
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the enzyme is myristoylated at the N-terminus within the pleckstrin homology PH domain, required for activity
phosphoprotein
ubiquitination
levels of CerK are downregulated by the ubiquitin/proteasome and lysosome pathways and the former pathway-sensitive pool of CerK is suggested to be linked with exocytosis in PC12 cells
phosphorylation of serine residues at positions 340 and 408, putative additional phosphorylation site at serine 427 lying in the calcium/calmodulin domain, preventing phosphorylation at S340 results in CERK instability
phosphoprotein
activity of CerK is regulated by post-translational modifications including phosphorylation