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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.4.2.B18physiological function enzyme acts as a bifunctional glycosyltransferase, with both xylosyltransferase and glucuronyltransferase activities, producing repeating units of [3-xylose-alpha-(1->3)-glucuronic acid-beta-1-]. LARGE synthesizes the polymer on the O-mannosyl glycan of alpha-dystroglycan in vivo. The LARGE-synthesized, negatively charged glycan on alpha-dystroglycan likely binds to laminin through electrostatic associations with these basic patches 760192
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