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Information on EC 2.4.2.B18 - alpha-dystroglycan xylosyltransferase

for references in articles please use BRENDA:EC2.4.2.B18
preliminary BRENDA-supplied EC number
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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.B18 alpha-dystroglycan xylosyltransferase
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
beta-D-glucuronosyl-[O-mannosyl-chain of alpha-dystroglycan]
=
+
alpha-D-xylosyl-(1->3)-beta-D-glucuronosyl-(1->3)-[O-mannosyl-chain of alpha-dystroglycan]
+
beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->3)-[3)-beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->]n-[O-mannosyl-chain of alpha-dystroglycan]
=
+
alpha-D-xylosyl-(1->3)-beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->3)-[3)-beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->]n-[O-mannosyl-chain of alpha-dystroglycan]]
Synonyms
LARGE1, like-acetylglucosaminyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-xylose + beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->3)-[3)-beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->]n-[O-mannosyl-chain of alpha-dystroglycan] = UDP + alpha-D-xylosyl-(1->3)-beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->3)-[3)-beta-D-glucuronosyl-(1->3)-alpha-D-xylosyl-(1->]n-[O-mannosyl-chain of alpha-dystroglycan]]
show the reaction diagram
(2)
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UDP-alpha-D-xylose + beta-D-glucuronosyl-[O-mannosyl-chain of alpha-dystroglycan] = UDP + alpha-D-xylosyl-(1->3)-beta-D-glucuronosyl-(1->3)-[O-mannosyl-chain of alpha-dystroglycan]
show the reaction diagram
(1)
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