EC Number   |
General Information |
Reference |
|---|
   2.4.2.60 | metabolism |
the enzyme synthesizes the thiazole precursor of thiamin |
758764 |
| 2.4.2.60 | physiological function |
an enzyme deletion mutant displays increased sensitivity to oxidative stress and enhanced thiamine diphosphate biosynthesis as compared with the wild-type strain |
744942 |
| 2.4.2.60 | physiological function |
enzyme is able to functionally replace Thi4 in yeast thiazole synthesis. CyPBP37 is a substrate of the chaperone activity of its own binding partner cyclophilin CyP41 |
-, 745546 |
| 2.4.2.60 | physiological function |
enzyme without active-site Cys is the major enzyme type in developing grains that saves substantial energy during the grain-filling period |
758764 |
| 2.4.2.60 | physiological function |
expression of Thi1 rescues a yeast Thi4 mutant when fused to the yeast Thi4 signal peptide |
746072 |
| 2.4.2.60 | physiological function |
protein Thi4 from Saccharomyces cerevisiae fails to catalyze the formation of the thiazole moiety from cysteine (or sulfide), glycine and a variety of C5 carbohydrates. Thi4 also fails to complement an Escherichia coli thiazole biosynthetic mutant ThiF. The ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid is present at the active site of Thi4 and the carboxylic acid of the thiazole forms hydrogen bonding and electrostatic interactions with Arg301 |
-, 745150 |
