EC Number   |
General Information |
Reference |
|---|
    1.1.1.49 | malfunction |
cells with glucose-6-phosphate dehydrogenase deficiency are susceptible to oxidant-induced death at high oxidative stress |
740908 |
| 1.1.1.49 | malfunction |
disruption of glucose-6-phosphate dehydrogenase (ZWF1), 6-phosphogluconate dehydrogenase GND1 and 6-phosphogluconate dehydrogenase GND2 genes can decrease the ability of yeast cells to reproduction in the exponential phase of culture |
-, 761585 |
| 1.1.1.49 | malfunction |
disruption of the gene zwf-1 results in increased alginate production when glycerol is used as the carbon source |
-, 739909 |
| 1.1.1.49 | malfunction |
enzyme-knockdown cells are susceptible to infection with coronavirus 229E and enterovirus 71 |
741464 |
| 1.1.1.49 | metabolism |
high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets. Inhibition of G6PD with siRNA leads to increase in reactive oxygen species and apoptosis, decreased proliferation, and impaired insulin secretion. High glucose level decreases insulin secretion, which is improved by overexpressing G6PD |
711960 |
| 1.1.1.49 | metabolism |
moderate overexpression of the enzyme (G6PD) can protect beta-cells from age-associated oxidative stress thus reducing the risk of developing type 2 diabetes |
761119 |
| 1.1.1.49 | metabolism |
rate-limiting enzyme of the pentose-phosphate pathway |
723747 |
| 1.1.1.49 | metabolism |
regulatory enzyme of the pentose phosphate pathway |
723340 |
| 1.1.1.49 | metabolism |
the bifunctional glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase enzyme catalyzes the first and second steps in the parasite's pentose phosphate pathway, cf. EC 3.1.1.31 |
730067 |
| 1.1.1.49 | metabolism |
the enzyme is one of the most important dehydrogenases responsible for generating reduced NADPH for anabolism and it is also the rate-limiting enzyme in the Entner-Doudoroff pathway |
-, 760410 |
