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Information on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

for references in articles please use BRENDA:EC1.1.1.49

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IUBMB Comments

The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).

The enzyme appears in viruses and cellular organisms

Synonyms
g6pd, glucose-6-phosphate dehydrogenase, g6pdh, g-6-pd, glucose 6-phosphate dehydrogenase, g-6-pdh, g-6pd, zwf-1, glucose-6-phosphate 1-dehydrogenase, glc6pdh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
cytosolic NADPH production (yeast), Entner-Doudoroff pathway I, formaldehyde oxidation I, heterolactic fermentation, pentose phosphate pathway (oxidative branch) I, superpathway of glycolysis and the Entner-Doudoroff pathway