EC Number   |
Application |
Reference |
|---|
   2.3.1.5 | analysis |
development and evaluation of genotoxicity screening sensors measuring DNA damage from metabolsim of arylamines and based on ultrathin films containing DNA and N-acetyltransferase on pyrolytic graphite electrodes. N-acetyltransferase in the film catalyzes the conversion of the arylamine 2-aminofluorene to 2-acetylaminofluorene by acetyl coenzyme A-dependent N-acetylation. DNA damage is measured subsequently using ctaalytic voltammetric oxidation with Ru(bpy)32+ |
701683 |
| 2.3.1.5 | analysis |
the NAT enzyme activates an arylhydroxamic acid functionality into a nitrenium ion that reacts fast, covalently, and under neutral conditions with nucleophilic residues of neighboring proteins. Strong labeling is only observed with an arylhydroxamic acid bearing an electron donating substituent. Clear labeling is achieved on a subcellular level in living cells that are transfected with a genetically targeted NAT to the nucleus or the cytosol |
755685 |
| 2.3.1.5 | drug development |
inhibitors of NAT enzymes may be valuable as chemopreventive agents |
677267 |
| 2.3.1.5 | drug development |
the enzyme is a target for development of anti-mycobacterial drugs |
-, 672567 |
| 2.3.1.5 | medicine |
a negative correlation is found between the expression of NAT1 and MMP9 in 1904 breast cancer samples |
757700 |
| 2.3.1.5 | medicine |
a polymorphic homologue of human NAT2 is characterized in the rhesus macaque, to facilitate investigations of the postulated involvement of this isoenzyme in the toxicogenetics of endometriosis |
689354 |
| 2.3.1.5 | medicine |
activity in benign prostatic hyperplasia tissue |
487150 |
| 2.3.1.5 | medicine |
activity in umbilical cord tissue from different samples |
487154 |
| 2.3.1.5 | medicine |
altered expression of the human orthologue in breast tumours, in which there is endocrine signalling, suggests that human NAT1 should be considered as a potential biomarker for neuroendocrine tissues and tumours |
685494 |
| 2.3.1.5 | medicine |
C1095A SNP outside the NAT1 coding region is associated with increased homocysteine. The C1095A SNP is found most frequently in the NAT1 allele 1*10 and is shown to have increase NAT1 activity or to have no effect. C1095A SNP appears at increased frequency in bladder cancer and Alzheimer's disease |
686618 |
