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Literature summary for 2.3.1.5 extracted from
- Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in breast cancer cells role of hypoxia-inducible factor 1-alpha (2019), Mol. Pharmacol., 96, 573-579 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a negative correlation is found between the expression of NAT1 and MMP9 in 1904 breast cancer samples | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P18440 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
| T-47D cell | - |
Homo sapiens | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | when NAT1 is deleted in highly invasive breast cancer cells, matrix metalloprotease MMP9 mRNA and protein significantly increase. After NAT1 deletion, there is an increased association of acetylated histone H3 with the SET and MYND-domain containing 3 element in the MMP9 promoter. NAT1 deletion also up-regulates hypoxia-inducible factor 1-alpha. Treatment of the NAT1 knockout cells with siRNA directed toward HIF1-alpha mRNA inhibits the increased expression of MMP9 | Homo sapiens |
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