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Results 1 - 7 of 7
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EC Number Application Commentary Reference
Display the reaction diagram Show all sequences 2.3.1.291medicine both isoforms CerS4 and CerS5 are up-regulated in endometrial and colon cancer cells. Apoptosis induction by anastrozole or 5-FU results in down-regulation of CerS4 and CerS5 in endometrial and colon cancer cells 753514
Display the reaction diagram Show all sequences 2.3.1.291medicine CerS1 and CerS5 mRNA expression is reduced in muscle biopsies from patients in advanced stage of chronic heart failure suffering from muscle wasting and frailty 752426
Display the reaction diagram Show all sequences 2.3.1.291medicine CerS5-dependent ceramide synthesis has a strong impact in white adipose tissue after high fat diet feeding 754142
Display the reaction diagram Show all sequences 2.3.1.291medicine in human breast cancer tissue, a significant increase in CerS4 and CerS6 mRNA is observed in estrogen receptor positive cancer tissue. The activities of CerS4 and CerS5 promoter constructs increase after estradiol treatment in MCF-7 cells. Estradiol and GPER1 mediate their effects on CerS4 and Cers5 promoter by activating AP-1, most likely through dimerization of c-Jun and c-Fos 752733
Display the reaction diagram Show all sequences 2.3.1.291medicine in human breast cancer tissue, a significant increase in CerS4 and CerS6 mRNA isobserved in estrogen receptor positive cancer tissue. The activities of CerS4 and CerS5 promoter constructs increase after estradiol treatment in MCF-7 cells. Estradiol and GPER1 mediate their effects on CerS4 and Cers5 promoter by activating AP-1, most likely through dimerization of c-Jun and c-Fos 752733
Display the reaction diagram Show all sequences 2.3.1.291medicine in human wild-type p53 HCT-116 colon cancer cells, treatment with oxaliplatin or 5-fluorouracil leads to a strong increase in ceramide synthase CerS5 expression and C16:0-ceramide levels, which is not seen in HCT-116 cells lacking p53 expression. The increase in CerS5 expression occurs by stabilizing CerS5 mRNA at the 3'-UTR 752815
Display the reaction diagram Show all sequences 2.3.1.291medicine long-chain ceramides are upregulated whereas very long-chain ceramides are downregulated in cell lines, mouse animal model, and patients with cystic fibrosis, compared with their controls. Treatment with fenretinide decreases the levels of long-chain ceramides and increases the levels of very long-chain ceramides 754455
Results 1 - 7 of 7
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