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Literature summary for 2.3.1.291 extracted from

  • Tosetti, B.; Brodesser, S.; Brunn, A.; Deckert, M.; Blueher, M.; Doehner, W.; Anker, S.D.; Wenzel, D.; Fleischmann, B.; Pongratz, C.; Peters, F.; Utermoehlen, O.; Kroenke, M.
    A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle (2019), Aging Cell, 19, e13049 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine CerS1 and CerS5 mRNA expression is reduced in muscle biopsies from patients in advanced stage of chronic heart failure suffering from muscle wasting and frailty Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N5B7 isoform CerS5
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Mus musculus Q9D6K9 isoform CerS5
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Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle an age-dependent decline of both isoforms CerS1 and CerS5 mRNA expression is observed in skeletal muscle biopsies Homo sapiens
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skeletal muscle the expression of CerS1 and CerS5 mRNA, encoding the ceramide synthases with substrate preference for C16:0 and C18:0 acyl chains, respectively, is downregulated in skeletal muscle of aged mice Mus musculus
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Expression

Organism Comment Expression
Mus musculus the expression of CerS1 and CerS5 mRNA, encoding the ceramide synthases with substrate preference for C16:0 and C18:0 acyl chains, respectively, is downregulated in skeletal muscle of aged mice down

General Information

General Information Comment Organism
physiological function skeletal muscle from mice deficient of either CerS1 or CerS5 shows reduced caliber sizes of both slow (type 1) and fast (type 2) muscle fibers, fiber grouping, and fiber switch to type 1 fibers. CerS1- and CerS5-deficient mice exhibit reduced twitch and tetanus forces of musculus extensor digitorum longus Mus musculus