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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.B74synthesis expression together with basil flavonoid 6-hydroxylase encoded by CYP82D33 and further ethyltransferases in Saccharomyces cerevisiae to produce 8- and/or 6-substituted, methoxylated flavones from their natural precursor apigenin. The yeast cells produce substantial amounts of 6-hydroxylated, methylated derivatives of naringenin and luteolin while the corresponding derivatives of flavonol kaempferol are only detected in trace amounts. The substrate specificity of both the hydroxylases and the flavonoid O-methyltransferases is limiting yields obtained with alternative substrates 755873
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