Literature summary for 2.1.1.B74 extracted from

Berim, A.; Gang, D.R.
Production of methoxylated flavonoids in yeast using ring A hydroxylases and flavonoid O-methyltransferases from sweet basil (2018), Appl. Microbiol. Biotechnol., 102, 5585-5598 .

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Application

Application	Comment	Organism
synthesis	expression together with basil flavonoid 6-hydroxylase encoded by CYP82D33 and further ethyltransferases in Saccharomyces cerevisiae to produce 8- and/or 6-substituted, methoxylated flavones from their natural precursor apigenin. The yeast cells produce substantial amounts of 6-hydroxylated, methylated derivatives of naringenin and luteolin while the corresponding derivatives of flavonol kaempferol are only detected in trace amounts. The substrate specificity of both the hydroxylases and the flavonoid O-methyltransferases is limiting yields obtained with alternative substrates	Ocimum basilicum

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Ocimum basilicum

Organism

Organism	UniProt	Comment	Textmining
Ocimum basilicum	K0I977	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + apigenin	-	Ocimum basilicum	S-adenosyl-L-homocysteine + genkwanin	-	?

Synonyms

Synonyms	Comment	Organism
F7OMT	-	Ocimum basilicum

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Release 2023.1 (January 2023)