Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | integral membrane protein | Rattus norvegicus | 16020 | - |
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | selenoprotein | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astroglial cell | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | substrate for type 1 iodothyronine deiodinase | Rattus norvegicus | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | substrate for type 2 iodothyronine deiodinase | Rattus norvegicus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 1 iodothyronine deiodinase | - |
Rattus norvegicus |
type 2 iodothyronine deiodinase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | incubation (for 2-12 h at 37°C) of confluent primary cultures of astroglial cells, maintained in a chemically defined medium devoid of growth factors and hormones, with various concentrations of adenosine, AMP, ADP, ATP (highest activity at 0. 1 mM after 4 h), and a series of their analogues causes a marked induction of type 2 iodothyronine deiodinase activity (up to 30fold basal level). Preincubation of cells with all-trans-retinoic acid multiplies the inducing effect of the purines (up to 42fold increase of type 1 iodothyronine deiodinase); all-trans retinoic acid itself enhances the activity of type 2 iodothyronine deiodinase, and also of type 1 iodothyronine deiodinase, only a little | up |