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3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
3,3',5,5'-tetraiodo-L-thyronine + AH2
?
-
-
-
?
3,3',5-triiodo-L-thyronine sulfate + reduced electron acceptor
diiodothyronine + iodide + electron acceptor
-
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
3,3',5-triiodothyronine + AH2
3,5-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodothyronine + AH2
diiodothyronine + iodide + A + H+
rT3 ORD activity
-
-
?
3,5'-diiodo-L-thyronine + AH2
3-iodothyronine + iodide + A + H+
-
-
-
-
?
3,5,3'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
assay at pH 7.2
-
-
?
L-3,5',3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
L-3,5'-diiodothyonine + AH2
L-3-iodothyronine + iodide + A + H+
-
-
-
-
?
L-3,5'-diiodothyronine + AH2
L-3-iodothyronine + iodide + A + H+
-
-
-
-
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5,3'-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
sulfated reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+ + ?
-
-
-
-
?
additional information
?
-
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
the reaction is catalyzed by the type 1 and 2 deiodinases
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I: degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I: degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I, degradation of 3,3',5'-triiodo-L-thyronine
hormonally inactive
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
substrate for type 1 iodothyronine deiodinase
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
rT3 ORD activity
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type II and type III
-
-
?
L-3,5',3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
-
5'-deionination by isozyme Dio1
-
-
?
L-3,5',3'-triiodothyronine + AH2
L-3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5,3'-triiodothyronine + iodide + A + H+
-
i.e. thyroxine
triiodothyrosine, a small 3,3'-T2 peak also occurs
-
?
L-3,5,3',5'-tetraiodothyronine + AH2
L-3,5,3'-triiodothyronine + iodide + A + H+
-
i.e. thyroxine
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isoenzyme Dio1
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
type II
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
thyronine 5-deiodinase type
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
outer ring iodothyronine deiodinase activity, T4 ORD activity
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
reaction with dithiothreitol
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
thyronine 5'-deiodinase type II
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
thyronine 5'-deiodinase type II
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
addition of I125 labelled T4 to measure the production of T3
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
activation and deactivation of thyroid hormone
-
-
r
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
the reaction is catalyzed by the type 1 and 2 deiodinases
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
r
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
assay at pH 7.2
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
isozyme type II
hormonally active
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
addition of I125 labelled T4 to measure the production of T3, using paper chromatography
-
-
?
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
substrate for type 2 iodothyronine deiodinase
-
-
?
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
-
-
-
?
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
the enzyme is regulated at the pretranslational level
-
-
?
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
-
-
-
?
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
?
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
-
-
-
-
?
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
-
-
-
r
reverse triiodothyronine + AH2
diiodothyronine + iodide + A + H+
-
-
-
-
?
additional information
?
-
-
selenium-level of cells influences the enzyme activity
-
-
?
additional information
?
-
-
the catalytic cycle of ID-1 involves a ping-pong bisubstrate reaction in which the selenol form of the enzyme (ESeH) reacts with L-thyroxine to form a selenenyl iodide intermediate (ESeI) with release of the deiodinated compound 3,5,3'-triiodo-L-thyronine, and a subsequent reaction between the selenenyl iodide intermediate and possibly a thiol cofactor regenerates the selenol form
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
isozyme Dio1 exhibits both phenolic and tyrosyl ring deiodination activity while isozyme Dio2 catalyzes only deiodinations of the phenolic ring, isozyme Dio3 catalyzes only deiodinations of the tyrosyl ring. T3, 3,3'-T2, and 3,5-T2 are also not deiodinated by Dio1 from HepG2 lysates
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
3,3',5-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type II and type III
-
-
?
3,3',5-triiodothyronine + AH2
3,5-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,5'-diiodo-L-thyronine + AH2
3-iodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
L-thyroxine + AH2
3,5,3'-triiodo-L-thyronine + iodide + A + H+
L-thyroxine + electron acceptor
3,3',5-triiodothyronine + iodide + reduced electron acceptor
the enzyme is regulated at the pretranslational level
-
-
?
L-thyroxine + reduced acceptor
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
additional information
?
-
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
isoenzyme type I
-
-
?
3,3',5'-triiodothyronine + AH2
3,3'-diiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
isoenzyme Dio1
-
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
isozymes type II and I, production of 3,3',5-triiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
-
-
-
?
L-thyroxine + AH2
3,3',5'-triiodothyronine + iodide + A + H+
-
idothyronine 5'-deiodinase type I
-
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
-
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
-
thyronine 5'-deiodinase type II
-
-
?
L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell
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L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
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L-thyroxine + AH2
3,3',5-triiodothyronine + iodide + A + H+
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thyronine 5'-deiodinase type II
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1.21.99.4 thyroxine 5'-deiodinase
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