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Information on EC 1.21.99.4 - thyroxine 5'-deiodinase

for references in articles please use BRENDA:EC1.21.99.4

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IUBMB Comments

The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.

The enzyme appears in viruses and cellular organisms

Synonyms
deiodinase, type 2 deiodinase, type 3 deiodinase, iodothyronine 5'-deiodinase, type 2 iodothyronine deiodinase, type 1 deiodinase, thyroxine 5'-deiodinase, type i iodothyronine deiodinase, type ii iodothyronine deiodinase, type 1 iodothyronine deiodinase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
-
-, -