Literature summary for 1.14.11.53 extracted from

Yu, F.; Wei, J.; Cui, X.; Yu, C.; Ni, W.; Bungert, J.; Wu, L.; He, C.; Qian, Z.
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response (2021), Nucleic Acids Res., 49, 5779-5797 .

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Protein Variants

Protein Variants	Comment	Organism
K86R/K321R	ROS-induced global mRNA m6A modification is completely blocked by mutant K86R/K321R overexpression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6P6C2	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
sumoylation	ROS promotes ALKBH5 sumoylation, which blocks m6A demethylase activity by inhibition of substrate accessibility. Overexpression of sumoylation-deficient ALKBH5 blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	ROS significantly induces global mRNA N6-methyladenosine levels by modulating ALKBH5 post-translational modifications, leading to the rapid and efficient induction of thousands of genes. DNA damage repair genes are ALKBH5 downstream targets induced by ROS. ROS promotes ALKBH5 SUMOylation through activating ERK/JNK signaling, leading to inhibition of ALKBH5m6A demethylase activity by blocking substrate accessibility	Homo sapiens

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Release 2023.1 (January 2023)