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Literature summary for 1.11.1.12 extracted from

  • Gao, S.Q.; Liu, J.Q.; Han, Y.L.; Deji, Q.Z.; Zhaba, W.D.; Deng, H.J.; Liu, X.L.; Zhou, M.L.
    Neuroprotective role of glutathione peroxidase 4 in experimental subarachnoid hemorrhage models (2020), Life Sci., 257, 118050 .
    View publication on PubMed
Search for more literature for 1.11.1.12

Protein Variants

Protein Variants Comment Organism
additional information replication-deficient human adenovirus containing rat GPX4 cDNA (adenovirus GPX4 [Ad-GPX4]) is used to overexpress GPX4 in rats by injection into the right lateral ventricle of the brain of male Sprague-Dawley rats Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] Rattus norvegicus
-
 glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
 ?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] Rattus norvegicus Sprague-Dawley
-
 glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P36970 male rats
-
Rattus norvegicus Sprague-Dawley P36970 male rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebral cortex
-
 Rattus norvegicus
-
neuron endogenous GPX4 is mainly expressed in neurons, usage of primary cultured cortical neurons Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
-
 Rattus norvegicus glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
 ?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
-
 Rattus norvegicus Sprague-Dawley glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
glutathione peroxidase 4
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus subarachnoid hemorrhage (SAH) reduces enzyme expression down

General Information

General Information Comment Organism
malfunction decrease of GPX4 expression potentially plays an important role in ferroptosis during early brain injury after SAH. Overexpression of GPX4 significantly reduces lipid peroxidation and cell death in the experimental SAH models both in vivo. Overexpression of GPX4 has a neuroprotective effect after SAH. Overexpression of GPX4 ameliorates brain edema and neurological deficits at 24 h after SAH Rattus norvegicus
physiological function early brain injury is an essential pathological process after subarachnoid hemorrhage (SAH), with many cell death modalities. Ferroptosis is a regulated cell death caused by the iron-dependent accumulation of lipid peroxidation, which can be prevented by glutathione peroxidase 4 (GPX4), role of GPX4 in neuronal cell death, overview. Among the various mechanisms of early brain injury, lipid peroxidation is an important mechanism and is closely related to a poor clinical outcome. The generation of oxidized phospholipid (oxPL) species plays a crucial role in ferroptosis13. Glutathione peroxidase 4 (GPX4) inhibits ferroptosis by acting as the sole enzyme to convert hydroperoxides into nontoxic lipid alcohols Rattus norvegicus