Application | Comment | Organism |
---|---|---|
medicine | therapy development for sexually transmitted disease of humans | Trichomonas vaginalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
oxaloacetate | - |
Trichomonas gallinae | |
oxaloacetate | - |
Trichomonas vaginalis | |
oxaloacetate | - |
Tritrichomonas suis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0106 | - |
NADH | Tv 10-02 | Trichomonas vaginalis | |
0.011 | - |
NADH | - |
Trichomonas gallinae | |
0.013 | - |
NADH | - |
Tritrichomonas suis | |
0.016 | - |
oxaloacetate | - |
Trichomonas gallinae | |
0.0162 | - |
oxaloacetate | Tv 10-02 | Trichomonas vaginalis | |
0.0175 | - |
oxaloacetate | - |
Tritrichomonas suis | |
0.02 | - |
NADH | Tv-1961 | Trichomonas vaginalis | |
0.02 | - |
oxaloacetate | Tv-1961 | Trichomonas vaginalis | |
0.02 | - |
NADH | Tv-1973 | Trichomonas vaginalis | |
0.022 | - |
NAD+ | Tv-1973 | Trichomonas vaginalis | |
0.043 | - |
oxaloacetate | Tv-1973 | Trichomonas vaginalis | |
0.0699 | - |
NAD+ | Tv 10-02 | Trichomonas vaginalis | |
0.07 | - |
NAD+ | - |
Trichomonas gallinae | |
0.2 | - |
L-malate | - |
Trichomonas gallinae | |
1 | - |
L-malate | Tv-1961 | Trichomonas vaginalis | |
1.22 | - |
L-malate | Tv 10-02 | Trichomonas vaginalis | |
1.4 | - |
L-malate | Tv-1973 | Trichomonas vaginalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Trichomonas vaginalis | 5829 | - |
hydrogenosome | - |
Trichomonas vaginalis | 42566 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34500 | - |
2 * 34500, SDS-PAGE | Trichomonas vaginalis |
37000 | - |
6 * 37000 | Tritrichomonas suis |
60000 | - |
gel filtration | Trichomonas vaginalis |
72000 | - |
gel filtration | Trichomonas gallinae |
244000 | - |
gel filtration | Tritrichomonas suis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
malate + NAD+ | Thermus aquaticus | - |
oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | Trichomonas vaginalis | - |
oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | Mycobacterium leprae | - |
oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | Tritrichomonas suis | - |
oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | Trichomonas gallinae | - |
oxaloacetate + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium leprae | - |
- |
- |
Thermus aquaticus | - |
- |
- |
Trichomonas gallinae | - |
- |
- |
Trichomonas vaginalis | - |
strain TV 10-02, strain Tv-1961, strain Tv-1973 | - |
Tritrichomonas suis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Trichomonas vaginalis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
352.7 | - |
- |
Trichomonas vaginalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NAD+ | - |
Thermus aquaticus | oxaloacetate + NADH + H+ | - |
r | |
(S)-malate + NAD+ | - |
Trichomonas vaginalis | oxaloacetate + NADH + H+ | - |
r | |
(S)-malate + NAD+ | - |
Mycobacterium leprae | oxaloacetate + NADH + H+ | - |
r | |
(S)-malate + NAD+ | - |
Tritrichomonas suis | oxaloacetate + NADH + H+ | - |
r | |
(S)-malate + NAD+ | - |
Trichomonas gallinae | oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | - |
Thermus aquaticus | oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | - |
Trichomonas vaginalis | oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | - |
Mycobacterium leprae | oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | - |
Tritrichomonas suis | oxaloacetate + NADH + H+ | - |
r | |
malate + NAD+ | - |
Trichomonas gallinae | oxaloacetate + NADH + H+ | - |
r | |
oxaloacetate + NADH | - |
Thermus aquaticus | L-malate + NAD+ | - |
r | |
oxaloacetate + NADH | - |
Trichomonas vaginalis | L-malate + NAD+ | - |
r | |
oxaloacetate + NADH | - |
Mycobacterium leprae | L-malate + NAD+ | - |
r | |
oxaloacetate + NADH | - |
Tritrichomonas suis | L-malate + NAD+ | - |
r | |
oxaloacetate + NADH | - |
Trichomonas gallinae | L-malate + NAD+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Thermus aquaticus |
dimer | 2 * 34500, SDS-PAGE | Trichomonas vaginalis |
hexamer | 6 * 37000 | Tritrichomonas suis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.3 | Tv 10-02, reduction of oxaloacetate | Trichomonas vaginalis |
7.8 | - |
strain Tv-1973 | Trichomonas vaginalis |
7.8 | 7.9 | Tv-1961, reduction of oxaloacetate | Trichomonas vaginalis |
8 | - |
oxaloacetate reduction | Tritrichomonas suis |
9 | - |
oxalacetate reduction | Trichomonas gallinae |
9 | - |
malate oxidation, above pH 9.0, strain Tv-1973 | Trichomonas vaginalis |
9.2 | 10.7 | malate oxidation, strain Tv-1961 | Trichomonas vaginalis |
9.5 | - |
reverse reaction from malate to oxalacetate | Trichomonas vaginalis |