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Information on EC 1.1.1.37 - (S)-malate dehydrogenase (NAD+, oxaloacetate-forming)

for references in articles please use BRENDA:EC1.1.1.37

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IUBMB Comments

There are several forms of malate dehydrogenases that differ in their use of substrates and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids and aromatic α-keto acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+), EC 1.1.1.299, malate dehydrogenase [NAD(P)+] and EC 1.1.5.4, malate dehydrogenase (quinone).

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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(S)-malate
+
NAD+
=
oxaloacetate
+
NADH
+
H+
+
=
+
+

Synonyms
malate dehydrogenase, mdh, mitochondrial malate dehydrogenase, malic dehydrogenase, cytosolic malate dehydrogenase, nad-dependent malate dehydrogenase, maldh, mitochondrial mdh, s-mdh, l-malate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-malate + NAD+ = oxaloacetate + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
(S)-lactate fermentation to propanoate, acetate and hydrogen, anaerobic energy metabolism (invertebrates, cytosol), C4 photosynthetic carbon assimilation cycle, NAD-ME type, formaldehyde assimilation I (serine pathway), gluconeogenesis I, gluconeogenesis III, glyoxylate cycle, incomplete reductive TCA cycle, malate/L-aspartate shuttle pathway, methylaspartate cycle, mixed acid fermentation, pyruvate fermentation to propanoate I, reductive TCA cycle I, reductive TCA cycle II, superpathway of glyoxylate cycle and fatty acid degradation, TCA cycle I (prokaryotic), TCA cycle II (plants and fungi), TCA cycle III (animals), TCA cycle IV (2-oxoglutarate decarboxylase), TCA cycle V (2-oxoglutarate synthase), TCA cycle VIII (Chlamydia)
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