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BRENDA support

Information on EC 1.3.99.8 - 2-furoyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.99.8

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IUBMB Comments

A copper protein. The oxygen atom of the -OH produced is derived from water, not O2; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH2-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
2-furoyl-coa dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
5-hydroxymethylfurfural degradation, furfural degradation
Highest Expressing Human Cell Lines
Cell Line Links Gene Links