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EC 1.14.21.7 Details
show Brenda entryEC number
1.14.21.7
Accepted name
biflaviolin synthase
Reaction
(1) 2 flaviolin + NADPH + H+ + O2 = 3,3′-biflaviolin + NADP+ + 2 H2O;;(2) 2 flaviolin + NADPH + H+ + O2 = 3,8′-biflaviolin + NADP+ + 2 H2O
Other name(s)
CYP158A2,
CYP 158A2,
cytochrome P450 158A2
Systematic name
flaviolin,NADPH:oxygen oxidoreductase
Comment
This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1].
History
created 2008, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000 1.14.99.6 created 1972, modified 2000, deleted 2000 1.14.99.8 created 1972, deleted 1984 1.14.99.13 created 1972, deleted 1984 1.14.99.16 created 1972, deleted 2002 1.14.99.17 created 1972, deleted 1976 1.14.99.18 created 1976, modified 1999, deleted 2003 1.14.99.25 created 1986, deleted 2000
