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EC 1.14.19.69 Details
show Brenda entryEC number
1.14.19.69
Accepted name
biflaviolin synthase
Reaction
(1) 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 3,3′-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O;;(2) 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 3,8′-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
Other name(s)
CYP158A2 (gene name),
cytochrome P450 158A2
Systematic name
flaviolin,reduced ferredoxin:oxygen oxidoreductase
Comment
This cytochrome-P-450 (heme-thiolate) enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1].
History
created 2008 as EC 1.14.21.7, transferred 2018 to EC 1.14.19.69
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.99.1 D-amino-acid dehydrogenase
