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EC 1.14.13.8 Details
EC number
1.14.13.8
Accepted name
flavin-containing monooxygenase
Reaction
N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O
Other name(s)
dimethylaniline oxidase,
dimethylaniline N-oxidase,
FAD-containing monooxygenase,
N,N-dimethylaniline monooxygenase,
DMA oxidase,
flavin mixed function oxidase,
Ziegler’s enzyme,
mixed-function amine oxidase,
FMO,
FMO-I,
FMO-II,
FMO1,
FMO2,
FMO3,
FMO4,
FMO5,
flavin monooxygenase,
methylphenyltetrahydropyridine N-monooxygenase,
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase,
dimethylaniline monooxygenase (N-oxide-forming)
Systematic name
N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)
CAS registry number
37256-73-8
Comment
A flavoprotein. A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines [3,4]. This enzyme is distinct from other monooxygenases in that the enzyme forms a relatively stable hydroperoxy flavin intermediate [4,5]. This microsomal enzyme generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites. For example, N-oxygenation is largely responsible for the detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [2,6]
History
created 1972 (EC 1.13.12.11 created 1992, part-incorporated 2006), modified 2006
EC Tree
1.14.11.5 created 1972, deleted 1976
1.14.13.45 created 1992, deleted 2003