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EC 1.14.13.200 Details
EC number
1.14.13.200
Accepted name
tetracenomycin A2 monooxygenase-dioxygenase
Reaction
tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ = tetracenomycin C + 2 NAD(P)+ + H2O
Other name(s)
TcmG,
ElmG,
tetracenomycin A2,NAD(P)H:O2 oxidoreductase (tetracenomycin C forming)
Systematic name
tetracenomycin A2,NAD(P)H:oxygen oxidoreductase (tetracenomycin-C-forming)
Comment
Isolated from the bacterium Streptomyces glaucescens. The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis. The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide. Water opens the epoxide giving two hydroxy groups. The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group.
History
created 2014
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