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EC 1.14.13.162 Details
show Brenda entryEC number
1.14.13.162
Accepted name
2,5-diketocamphane 1,2-monooxygenase
Reaction
(+)-bornane-2,5-dione + O2 + NADH + H+ = (+)-5-oxo-1,2-campholide + NAD+ + H2O
Other name(s)
2,5-diketocamphane lactonizing enzyme,
ketolactonase I (ambiguous),
2,5-diketocamphane 1,2-monooxygenase oxygenating component,
2,5-DKCMO,
camP (gene name),
camphor 1,2-monooxygenase,
camphor ketolactonase I
Systematic name
(+)-bornane-2,5-dione,NADH:oxygen oxidoreductase (1,2-lactonizing)
Comment
A flavoprotein (FMN) which requires Fe2+. A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid. Involved in the degradation of (+)-camphor. Requires a dedicated NADH-FMN reductase [cf. EC 1.5.1.42, FMN reductase (NADH)] [1-3]. Can accept several bicyclic ketones including (+)- and (–)-camphor [6] and adamantanone [4]. The product spontaneously converts to [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate.
History
created 1972 as EC 1.14.15.2, transferred 2012 to EC 1.14.13.162, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
