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EC 7.5.2.5 Details

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EC number

7.5.2.5

Accepted name

ABC-type lipopolysaccharide transporter

Reaction

ATP + H₂O + lipopolysaccharide_{[side 1]} = ADP + phosphate + lipopolysaccharide_{[side 2]}

Other name(s)

lptB (gene name), lipopolysaccharide transport system, lipopolysaccharide-transporting ATPase

Systematic name

ATP phosphohydrolase (ABC-type, lipopolysaccharide-exporting)

Comment

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzyme, characterized from the bacterium Escherichia coli, functions as part of the lipopolysaccharide (LPS) export system, a seven protein system that translocates LPS from the inner- to the outer membrane. The ATPase activity in this system is implicated in releasing LPS from the inner membrane.

History

created 2000 as EC 3.6.3.39, transferred 2018 to EC 7.5.2.5

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

7.1 Catalysing the translocation of hydrons

7.2 Catalysing the translocation of inorganic cations

7.3 Catalysing the translocation of inorganic anions and their chelates

7.4 Catalysing the translocation of amino acids and peptides

7.5 Catalysing the translocation of carbohydrates and their derivatives

7.5.2 Linked to the hydrolysis of a nucleoside triphosphate

7.5.2.1 ABC-type maltose transporter

7.5.2.2 ABC-type oligosaccharide transporter

7.5.2.3 ABC-type β-glucan transporter

7.5.2.4 ABC-type teichoic-acid transporter

7.5.2.5 ABC-type lipopolysaccharide transporter

7.5.2.6 ABC-type lipid A-core oligosaccharide transporter

7.5.2.7 ABC-type D-ribose transporter

7.5.2.8 ABC-type D-allose transporter

7.5.2.9 ABC-type D-galactofuranose transporter

7.5.2.10 ABC-type D-xylose transporter

7.5.2.11 ABC-type D-galactose transporter

7.5.2.12 ABC-type L-arabinose transporter

7.5.2.13 ABC-type D-xylose/L-arabinose transporter

7.6 Catalysing the translocation of other compounds