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EC 5.1.1.17 Details

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EC number

5.1.1.17

Accepted name

isopenicillin-N epimerase

Reaction

isopenicillin N = penicillin N

Systematic name

penicillin-N 5-amino-5-carboxypentanoyl-epimerase

CAS registry number

88201-43-8

Comment

This enzyme contains pyridoxal phosphate. Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, deactoxycephalosporin-C synthase, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway (for pathway, click here).

History

created 2002

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.22.1 With NAD⁺ or NADP⁺ as acceptor

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.1 alanine racemase

5.1.1.2 methionine racemase

5.1.1.3 glutamate racemase

5.1.1.4 proline racemase

5.1.1.5 lysine racemase

5.1.1.6 threonine racemase

5.1.1.7 diaminopimelate epimerase

5.1.1.8 4-hydroxyproline epimerase

5.1.1.9 arginine racemase

5.1.1.10 amino-acid racemase

5.1.1.11 phenylalanine racemase (ATP-hydrolysing)

5.1.1.12 ornithine racemase

5.1.1.13 aspartate racemase

5.1.1.14 nocardicin A epimerase

5.1.1.15 2-aminohexano-6-lactam racemase

5.1.1.16 protein-serine epimerase

5.1.1.17 isopenicillin-N epimerase

5.1.1.18 serine racemase

5.1.1.19 O-ureido-serine racemase

5.1.1.20 L-Ala-D/L-Glu epimerase

5.1.1.21 isoleucine 2-epimerase

5.1.1.22 4-hydroxyproline betaine 2-epimerase

5.1.1.23 UDP-N-acetyl-α-D-muramoyl-L-alanyl-L-glutamate epimerase

5.1.1.24 histidine racemase

5.1.2 Acting on hydroxy acids and derivatives

5.1.3 Acting on carbohydrates and derivatives

5.1.99 Acting on other compounds

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.4 Intramolecular transferases

5.5 Intramolecular lyases

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

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Release 2023.1 (January 2023)