EC Explorer

1.3.99.36

cypemycin cysteine dehydrogenase (decarboxylating)

cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys + acceptor = C^3.19,S²¹-cyclocypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO₂ + H₂S + reduced acceptor

cypemycin decarboxylase, CypD

cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys:acceptor oxidoreductase (decarboxylating, cyclizing)

Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.

created 2014