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EC 1.3.99.27 Details
show Brenda entryEC number
1.3.99.27
Accepted name
1-hydroxycarotenoid 3,4-desaturase
Reaction
1-hydroxy-1,2-dihydrolycopene + acceptor = 1-hydroxy-3,4-didehydro-1,2-dihydrolycopene + reduced acceptor
Other name(s)
CrtD,
hydroxyneurosporene desaturase,
carotenoid 3,4-dehydrogenase,
1-hydroxy-carotenoid 3,4-dehydrogenase
Systematic name
1-hydroxy-1,2-dihydrolycopene:acceptor oxidoreductase
Comment
The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides prefer the acyclic carotenoids (e.g. 1-hydroxy-1,2-dihydroneurosporene, 1-hydroxy-1,2-dihydrolycopene) as substrates. The conversion rate for the 3,4-desaturation of the monocyclic 1′-hydroxy-1′,2′-dihydro-γ-carotene is lower [2,3]. The enzyme from the marine bacterium strain P99-3 shows high activity with the monocyclic carotenoid 1′-hydroxy-1′,2′-dihydro-γ-carotene [1]. The enzyme from Rhodobacter sphaeroides utilizes molecular oxygen as the electron acceptor in vitro [3]. However, oxygen is unlikely to be the natural electron acceptor under anaerobic conditions.
History
created 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.3.1.23 created 1972, deleted 2005 1.3.1.50 created 1992, deleted 1999 1.3.1.55 created 1999, deleted 2004 1.3.99.9 created 1976, deleted 2002
